Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820593 | 0.89 | HCRTR2 (0.45) | HCRTR2EGLN1GSK3BNOTUMFBP1 | |
| SCHEMBL1167684 | 0.84 | PIN1 (0.51) | HCRTR2EGLN1GSK3BNOTUMFBP1 | |
| SCHEMBL6365318 | 0.84 | GSK3B (0.57) | EGLN1GSK3BNOTUMFBP1ADORA2A | |
| SCHEMBL9125394 | 0.81 | GSK3B (0.64) | HCRTR2GSK3BNOTUMFBP1ADORA2A | |
| SCHEMBL1969272 | 0.80 | ADORA2A (0.64) | HCRTR2GSK3BFBP1ADORA2AMEN1 | |
| SCHEMBL1167542 | 0.80 | FBP1 (0.47) | GSK3BFBP1ADORA2AMEN1KMT2A | |
| SCHEMBL1166876 | 0.79 | GSK3B (0.50) | HCRTR2GSK3BFBP1ADORA2AMEN1 | |
| SCHEMBL1969052 | 0.79 | HCRTR2 (0.50) | HCRTR2GSK3BNOTUMFBP1ADORA2A | |
| SCHEMBL5474080 | 0.78 | LOXL2 (0.51) | HCRTR2GSK3BFBP1ADORA2AMEN1 | |
| SCHEMBL1166776 | 0.78 | GSK3B (0.49) | HCRTR2GSK3BFBP1ADORA2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060589-A1 | Inhibitors of protein arginine methyl transferases | BRISTOL-MYERS SQUIBB COMPANY | 2007-03-15 | — | — | US | disclosed |
| WO-2006069155-A2 | INHIBITORS OF PROTEIN ARGININE METHYL TRANSFERASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060589-A1 | Inhibitors of protein arginine methyl transferases | PRMT1, PRMT3, PRMT6 | HCRTR2 4705/4885EGLN1 3222/4885GSK3B 704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.