Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5475281 | 1.00 | ALDH1A1 (0.53) | ALDH1A1CYP3A4HPGDCYP2C19ATM | |
| SCHEMBL5484578 | 0.88 | CYP3A4 (0.66) | CYP3A4HPGDCYP2C19ATMCYP1A2 | |
| SCHEMBL5484573 | 0.88 | CYP3A4 (0.66) | CYP3A4HPGDCYP2C19ATMCYP1A2 | |
| SCHEMBL5486508 | 0.88 | MAPT (0.59) | ALDH1A1CYP3A4HPGDCYP2C19ATM | |
| SCHEMBL5486515 | 0.88 | MAPT (0.59) | ALDH1A1CYP3A4HPGDCYP2C19ATM | |
| SCHEMBL5480628 | 0.88 | KDM4E (0.57) | ALDH1A1HPGDKDM4ECYP1A2CYP2C9 | |
| SCHEMBL5480632 | 0.88 | KDM4E (0.57) | ALDH1A1HPGDKDM4ECYP1A2CYP2C9 | |
| SCHEMBL5478757 | 0.88 | KDM4E (0.60) | ALDH1A1CYP3A4HPGDCYP2C19ATM | |
| SCHEMBL5478754 | 0.88 | KDM4E (0.60) | ALDH1A1CYP3A4HPGDCYP2C19ATM | |
| SCHEMBL5484698 | 0.83 | PDE4A (0.67) | ALDH1A1KDM4ECYP1A2CYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256219-B2 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-08-14 | — | — | US | claimed |
| US-20040171637-A1 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2004-09-02 | — | — | US | claimed |
| WO-2002072544-A2 | MULTIFLUORO-SUBSTITUTED CHALCONES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-09-19 | — | — | WO | claimed |
| US-7256219-B2 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-08-14 | — | — | US | disclosed |
| US-20040171637-A1 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2004-09-02 | — | — | US | disclosed |
| WO-2002072544-A2 | MULTIFLUORO-SUBSTITUTED CHALCONES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171637-A1 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP10, CASP6, CASP1 | ALDH1A1 821/4885CYP3A4 544/4885HPGD 2045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.