Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | MAOB | P27338 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | P4HB | P07237 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5486508 | 1.00 | MAPT (0.59) | MAPTHTTMAOBMEN1LMNA | |
| SCHEMBL5478754 | 0.89 | KDM4E (0.60) | MAPTHTTMEN1KMT2AKDM4E | |
| SCHEMBL5478757 | 0.89 | KDM4E (0.60) | MAPTHTTMEN1KMT2AKDM4E | |
| SCHEMBL5475283 | 0.88 | ALDH1A1 (0.53) | MAPTHTTMEN1KMT2AKDM4E | |
| SCHEMBL5475281 | 0.88 | ALDH1A1 (0.53) | MAPTHTTMEN1KMT2AKDM4E | |
| SCHEMBL5482543 | 0.87 | KDM4E (0.58) | MAPTHTTMAOBMEN1KMT2A | |
| SCHEMBL5482544 | 0.87 | KDM4E (0.58) | MAPTHTTMAOBMEN1KMT2A | |
| SCHEMBL5484573 | 0.87 | CYP3A4 (0.66) | MAPTMAOBMEN1LMNAKMT2A | |
| SCHEMBL5484578 | 0.87 | CYP3A4 (0.66) | MAPTMAOBMEN1LMNAKMT2A | |
| SCHEMBL5480480 | 0.84 | HSP90AA1 (0.53) | MAPTHTTMAOBLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256219-B2 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-08-14 | — | — | US | claimed |
| US-20040171637-A1 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2004-09-02 | — | — | US | claimed |
| WO-2002072544-A2 | MULTIFLUORO-SUBSTITUTED CHALCONES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-09-19 | — | — | WO | claimed |
| US-7256219-B2 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-08-14 | — | — | US | disclosed |
| US-20040171637-A1 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2004-09-02 | — | — | US | disclosed |
| WO-2002072544-A2 | MULTIFLUORO-SUBSTITUTED CHALCONES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171637-A1 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP10, CASP6, CASP1 | MAPT 4396/4885HTT 3382/4885MAOB 3638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.