SCHEMBL5480486

SCHEMBL5480486

Cc1ccc(C2=CCC(C)(C)c3ccc(C#Cc4ccccc4C(=O)O)cc32)cc1

nearest known ligand 0.73

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
RARB P10826 19/20 0.73
RARA P10276 18/20 0.73
RARG P13631 18/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8772792 0.92 RARB (0.61) RARBRARARARG
SCHEMBL8328655 0.85 RARB (0.52) RARBRARARARG
SCHEMBL8772626 0.85 RARA (0.62) RARBRARARARG
SCHEMBL30100837 0.84 RARB (1.00) RARBRARARARG
SCHEMBL346037 0.84 RARB (1.00) RARBRARARARG
SCHEMBL8508583 0.82 RARA (0.58) RARBRARARARG
SCHEMBL8721374 0.81 RARB (0.60) RARBRARARARG
SCHEMBL19342912 0.81 RARA (0.73) RARBRARARARG
SCHEMBL8772660 0.81 RARA (0.53) RARBRARARARG
SCHEMBL8326970 0.80 RARA (0.54) RARBRARARARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070049579-A1 Medicament having neovascularization promoting action Nagai, Ryozo (JP) 2007-03-01 US claimed