Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 17/20 | 0.43 |
| ▸ | AKT2 | P31751 | 16/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 7/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1434629 | 0.79 | AKT1 (0.72) | AKT1AKT2AKT3OPRL1OPRM1 | |
| SCHEMBL2439564 | 0.78 | AKT1 (0.49) | AKT1AKT2AKT3OPRL1OPRM1 | |
| SCHEMBL2439485 | 0.77 | AKT1 (0.50) | AKT1AKT2AKT3OPRL1OPRM1 | |
| SCHEMBL5261966 | 0.72 | ALDH1A1 (0.59) | AKT1AKT2AKT3 | |
| SCHEMBL5260840 | 0.72 | AKT1 (0.68) | AKT1AKT2AKT3 | |
| SCHEMBL5257804 | 0.68 | AKT1 (0.56) | AKT1AKT2AKT3 | |
| SCHEMBL7063258 | 0.68 | CCR8 (0.52) | OPRL1OPRM1OPRK1 | |
| SCHEMBL14104473 | 0.67 | AKT1 (0.46) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL27651183 | 0.66 | AKT1 (0.47) | AKT1AKT2AKT3OPRL1 | |
| SCHEMBL27651182 | 0.66 | AKT1 (0.47) | AKT1AKT2AKT3OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558586-A4 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2007-06-27 | — | — | EP | claimed |
| EP-1558586-A2 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | claimed |
| WO-2004041162-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | claimed |