SCHEMBL5481598

SCHEMBL5481598

O=C(O)Cc1ccc(NC(=O)c2c(Cl)cccc2Cl)c(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.50
MEN1 O00255 4/20 0.48
KMT2A Q03164 4/20 0.48
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.44
SLC16A3 O15427 1/20 0.44
KDM4E B2RXH2 2/20 0.44
GAA P10253 1/20 0.44
CAMK2A Q9UQM7 1/20 0.44
AKR1B1 P15121 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
NPSR1 Q6W5P4 1/20 0.43
HSD17B10 Q99714 1/20 0.43
JAK2 O60674 1/20 0.43
CYP3A4 P08684 1/20 0.43
JAK1 P23458 1/20 0.43
TYK2 P29597 1/20 0.43
CRHBP P24387 1/20 0.43
HTT P42858 1/20 0.43
CRHR2 Q13324 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14491718 0.85 MEN1 (0.48) MEN1KMT2AALDH1A1MAPTGAA
SCHEMBL5150193 0.81 MEN1 (0.52) CA2MEN1KMT2AALDH1A1MAPT
SCHEMBL1285674 0.79 CA2 (0.56) CA2MEN1KMT2AALDH1A1MAPT
SCHEMBL3183787 0.77 ALDH1A1 (0.45) ALDH1A1MAPTKDM4EGAASMN1; SMN2
SCHEMBL2434822 0.77 MAPT (0.47) MEN1KMT2AALDH1A1MAPTKDM4E
SCHEMBL5151792 0.77 MEN1 (0.55) CA2MEN1KMT2AMAPTKDM4E
SCHEMBL27588261 0.77 CXCL8 (0.64) MEN1KMT2ASLC16A3CAMK2ANR1H4
SCHEMBL14491730 0.76 POLB (0.50) CA2MEN1KMT2AMAPTKDM4E
SCHEMBL4154916 0.75 CA2 (0.59) CA2MEN1KMT2AALDH1A1MAPT
SCHEMBL6537481 0.75 MAPT (0.46) MEN1KMT2AALDH1A1MAPTSLC16A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070149606-A1 Process for producing phenylacetic acid derivative DAIICHI PHARMACEUTICAL CO.,LTD. (JP) 2007-06-28 US disclosed
US-20070149606-A1 Process for producing phenylacetic acid derivative DAIICHI PHARMACEUTICAL CO.,LTD. (JP) 2007-06-28 US disclosed
US-20070149606-A1 Process for producing phenylacetic acid derivative DAIICHI PHARMACEUTICAL CO.,LTD. (JP) 2007-06-28 US disclosed
EP-1698611-A1 PROCESS FOR PRODUCING PHENYLACETIC ACID DERIVATIVE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-09-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070149606-A1 Process for producing phenylacetic acid derivative UGT1A4, VPS4B, CYP3A4 CA2 1276/4885MEN1 4443/4885KMT2A 239/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.