Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | NOS3 | P29474 | 3/20 | 0.50 |
| ▸ | NOS1 | P29475 | 3/20 | 0.50 |
| ▸ | NOS2 | P35228 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22983154 | 0.79 | NOS3 (0.52) | LMNAKDM4EALDH1A1GAANPC1 | |
| SCHEMBL2931024 | 0.77 | NPC1 (0.56) | LMNAKDM4EALDH1A1GAANPC1 | |
| SCHEMBL22983751 | 0.75 | NOS3 (0.57) | LMNAKDM4EALDH1A1GAANPC1 | |
| SCHEMBL7638391 | 0.75 | KDM4E (0.54) | LMNAKDM4EALDH1A1GAANPC1 | |
| SCHEMBL11329885 | 0.75 | MAPT (0.44) | LMNAKDM4EALDH1A1GAANPC1 | |
| SCHEMBL11346261 | 0.75 | BLM (0.43) | LMNAKDM4EALDH1A1GAANPC1 | |
| SCHEMBL11330892 | 0.75 | ESR1 (0.38) | LMNAKDM4EALDH1A1GAANPC1 | |
| SCHEMBL2524831 | 0.74 | MAPT (1.00) | LMNAKDM4EALDH1A1GAANPC1 | |
| SCHEMBL6975593 | 0.74 | LMNA (0.53) | LMNAKDM4EALDH1A1GAANPC1 | |
| SCHEMBL341904 | 0.72 | KDM4E (0.47) | LMNAKDM4EALDH1A1GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070049583-A1 | Benzoxazine and benzothiazine derivatives and their use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2007-03-01 | — | — | US | disclosed |
| US-7141566-B1 | Benzoxazine and benzothiazine derivatives and the use thereof in medicaments | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-11-28 | — | — | US | disclosed |
| US-6914059-B2 | Benzoxazine and benzothiazine derivatives and the use thereof in medicaments | SCHERING AG (DE) | 2005-07-05 | — | — | US | disclosed |
| US-20050119481-A1 | Novel amidine derivatives and the use of the same in pharmaceuticals | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-06-02 | — | — | US | disclosed |
| EP-1453794-A1 | NOVEL AMIDINE DERIVATIVES AND THE USE OF THE SAME IN PHARMACEUTICALS | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-09-08 | — | — | EP | disclosed |
| US-20040006075-A1 | Benzoxazine and benzothiazine derivatives and the use thereof in medicaments | SCHERING AG (DE) | 2004-01-08 | — | — | US | disclosed |
| WO-2003053914-A1 | NOVEL AMIDINE DERIVATIVES AND THE USE OF THE SAME IN PHARMACEUTICALS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-07-03 | — | — | WO | disclosed |
| EP-1282610-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THE USE THEREOF IN MEDICAMENTS | Schering Aktiengesellschaft (DE) | 2003-02-12 | — | — | EP | disclosed |
| EP-1206458-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THE USE THEREOF IN MEDICAMENTS | Schering Aktiengesellschaft (DE) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001081323-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THE USE THEREOF IN MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-11-01 | — | — | WO | disclosed |
| WO-2001014347-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THE USE THEREOF IN MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-03-01 | — | — | WO | disclosed |
| US-4307092-A | 1-Oxo-5H-pyrimido[2,1-C]benzoxazine-2-carboxylic acid esters | AYERST MCKENNA & HARRISON, INC. (CA) | 1981-12-22 | — | — | US | disclosed |
| US-4254121-A | 3-Oxo-5H-pyrimido[2,1-c][1,4 ]benzoxazines | AYERST, MCKENNA & HARRISON INC. (CA) | 1981-03-03 | — | — | US | disclosed |
| US-4254118-A | 1-Oxo-5H-pyrimido[2,1-c][1,4]benzthiazine-2-carboxylic acid esters | AYERST, MCKENNA & HARRISON INC. (CA) | 1981-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006075-A1 | Benzoxazine and benzothiazine derivatives and the use thereof in medicaments | CYP4Z1, XDH, CYP3A5 | LMNA 1425/4885KDM4E 3426/4885ALDH1A1 998/4885 |
| US-20050119481-A1 | Novel amidine derivatives and the use of the same in pharmaceuticals | NGLY1, OAT, SLC10A1 | LMNA 2598/4885KDM4E 4508/4885ALDH1A1 4216/4885 |
| US-20070049583-A1 | Benzoxazine and benzothiazine derivatives and their use in pharmaceutical agents | CYP3A5, XDH, CYP4Z1 | LMNA 1572/4885KDM4E 3444/4885ALDH1A1 869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.