SCHEMBL5482437

SCHEMBL5482437

O=S(=O)(c1ccccc1)c1ccsc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 4/20 0.61
HSD11B1 P28845 1/20 0.46
LOX P28300 2/20 0.42
NPSR1 Q6W5P4 1/20 0.42
MAOA P21397 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.42
CYP2E1 P05181 1/20 0.41
CYP2A6 P11509 1/20 0.41
CYP2B6 P20813 1/20 0.41
ALDH1A1 P00352 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
TSHR P16473 2/20 0.39
HSD17B10 Q99714 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA3 P07451 1/20 0.39
CA4 P22748 1/20 0.39
CA6 P23280 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3272540 0.89 HTR6 (0.39) HTR6HSD11B1ALDH1A1TSHR
(Phenylsulfonyl)Benzene SCHEMBL29090883 0.79 HTR6 (0.70) HTR6LOXNPSR1MAOALOXL2
SCHEMBL11401258 0.79 HSD11B1 (0.44) HTR6HSD11B1NPSR1CYP2E1CYP2A6
SCHEMBL15285333 0.79 GAA (0.64) ALDH1A1SMN1; SMN2TDP1CA12CA1
(Phenylsulfonyl)Benzene SCHEMBL29473549 0.78 HTR6 (1.00) HTR6ALDH1A1SMN1; SMN2TSHRHSD17B10
(Phenylsulfonyl)Benzene SCHEMBL29450723 0.78 HTR6 (1.00) HTR6ALDH1A1SMN1; SMN2TSHRHSD17B10
(Phenylsulfonyl)Benzene SCHEMBL29775288 0.78 HTR6 (1.00) HTR6ALDH1A1SMN1; SMN2TSHRHSD17B10
(Phenylsulfonyl)Benzene SCHEMBL13735236 0.78 HTR6 (1.00) HTR6ALDH1A1SMN1; SMN2TSHRHSD17B10
(Phenylsulfonyl)Benzene SCHEMBL30255 0.78 HTR6 (1.00) HTR6ALDH1A1SMN1; SMN2TSHRHSD17B10
(Phenylsulfonyl)Benzene SCHEMBL28119187 0.78 HTR6 (1.00) HTR6ALDH1A1SMN1; SMN2TSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024098538-A1 METHOD FOR MANUFACTURING SOLAR CELL BY DOPING PEROVSKITE BULK WITH SULFONYL MOLECULES 中国科学院合肥物质科学研究院 2024-05-16 WO claimed
CN-115633531-A Method for preparing solar cell by doping sulfonyl molecules in perovskite phase 中国科学院合肥物质科学研究院 2023-01-20 CN claimed
WO-2024098538-A1 METHOD FOR MANUFACTURING SOLAR CELL BY DOPING PEROVSKITE BULK WITH SULFONYL MOLECULES 中国科学院合肥物质科学研究院 2024-05-16 WO disclosed
CN-115633531-A Method for preparing solar cell by doping sulfonyl molecules in perovskite phase 中国科学院合肥物质科学研究院 2023-01-20 CN disclosed
US-11446398-B2 Regulated biocircuit systems OBSIDIAN THERAPEUTICS, INC. (US) 2022-09-20 US disclosed
US-8008425-B2 Thiophene compound having sulfonyl group and process for producing the same NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-08-30 US disclosed
US-8008425-B2 Thiophene compound having sulfonyl group and process for producing the same NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-08-30 US disclosed
US-20090127491-A1 THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-05-21 US disclosed
US-20090127491-A1 THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-05-21 US disclosed
EP-1083980-B1 MODULATION OF MOLECULAR INTERACTION SITES ON RNA AND OTHER BIOMOLECULES ISIS PHARMACEUTICALS INC (US) 2007-03-21 EP disclosed
US-6969763-B1 Molecular interaction sites of interleukin-2 RNA and methods of modulating the same ISIS PHARMACEUTICALS, INC. (US) 2005-11-29 US disclosed
WO-2003091268-A1 MOLECULAR INTERACTION SITES OF VIMENTIN RNA AND METHODS OF MODULATING THE SAME ISIS PHARMACEUTICALS, INC. (US) 2003-11-06 WO disclosed
US-6492403-B1 TREATING SYMPTOMS OF ACUTE OR CHRONIC DISORDER MEDIATED BY CLASSICAL PATHWAY OF COMPLEMENT CASCADE; PROTEASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. 2002-12-10 US disclosed
EP-1083980-A2 MODULATION OF MOLECULAR INTERACTION SITES ON RNA AND OTHER BIOMOLECULES ISIS PHARMACEUTICALS, INC. (US) 2001-03-21 EP disclosed
EP-1077993-A1 GENERATION OF COMBINATORIAL LIBRARIES OF COMPOUNDS CORRESPONDING TO VIRTUAL LIBRARIES OF COMPOUNDS ISIS PHARMACEUTICALS, INC. (US) 2001-02-28 EP disclosed
WO-1999058947-A9 MODULATION OF MOLECULAR INTERACTION SITES ON RNA AND OTHER BIOMOLECULES ISIS PHARMACEUTICALS INC (US) 2000-04-20 WO disclosed
WO-1999058474-A9 GENERATION OF COMBINATORIAL LIBRARIES OF COMPOUNDS CORRESPONDING TO VIRTUAL LIBRARIES OF COMPOUNDS ISIS PHARMACEUTICALS INC (US) 2000-02-03 WO disclosed
WO-1999058947-A2 MODULATION OF MOLECULAR INTERACTION SITES ON RNA AND OTHER BIOMOLECULES ISIS PHARMACEUTICALS, INC. (US) 1999-11-18 WO disclosed
WO-1999058474-A1 GENERATION OF COMBINATORIAL LIBRARIES OF COMPOUNDS CORRESPONDING TO VIRTUAL LIBRARIES OF COMPOUNDS ISIS PHARMACEUTICALS, INC. (US) 1999-11-18 WO disclosed
EP-0203438-A1 Solution processible forms of neutral and electrically conductive poly(substituted heterocycles) ALLIED CORPORATION (US) 1986-12-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090127491-A1 THIOPHENE COMPOUND HAVING SULFONYL GROUP AND PROCESS FOR PRODUCING THE SAME TST, ABCG2, CBR3 HTR6 590/4885HSD11B1 965/4885LOX 3272/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.