Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | CCR3 | P51677 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5474202 | 0.89 | ALDH1A1 (0.71) | NAMPTMAPTRECQLKDM4EALDH1A1 | |
| SCHEMBL18502025 | 0.89 | L3MBTL3 (0.67) | SLC6A2SLC6A4SMN1; SMN2TMEM97CCR3 | |
| SCHEMBL1384427 | 0.88 | ALDH1A1 (0.72) | NAMPTMAPTRECQLKDM4EALDH1A1 | |
| SCHEMBL14430712 | 0.87 | SLC6A2 (0.69) | NAMPTSLC6A2SLC6A4MAPTRECQL | |
| SCHEMBL2251287 | 0.85 | MAPT (0.62) | NAMPTMAPTRECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL2555571 | 0.85 | CCR3 (0.67) | NAMPTKDM4EALDH1A1SMN1; SMN2CCR3 | |
| SCHEMBL20922550 | 0.85 | L3MBTL3 (0.61) | SLC6A2SLC6A4TMEM97CCR3L3MBTL3 | |
| SCHEMBL14430677 | 0.84 | CHRM4 (0.62) | NAMPTMAPTRECQLKDM4EALDH1A1 | |
| SCHEMBL16151552 | 0.84 | DRD2 (0.61) | NAMPTSLC6A2SLC6A4MAPTRECQL | |
| SCHEMBL5477836 | 0.82 | OPRL1 (0.66) | KDM4EALDH1A1GFERGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | GRIN2C, TPH2, HTR5A | NAMPT 3438/4885SLC6A2 73/4885SLC6A4 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.