Thiophene

Thiophene

SCHEMBL5483607

O=C(O)c1ccccc1CBr.c1ccsc1

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 3/20 0.49
ALDH1A1 P00352 8/20 0.45
ALOX15 P16050 2/20 0.45
TSHR P16473 1/20 0.45
CYP2C9 P11712 1/20 0.41
TP53 P04637 1/20 0.41
HTT P42858 1/20 0.41
GAA P10253 1/20 0.40
HIF1A Q16665 1/20 0.40
KDM4E B2RXH2 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
HMGB1 P09429 1/20 0.39
HPGD P15428 1/20 0.39
CA4 P22748 1/20 0.39
CA6 P23280 1/20 0.39
CA7 P43166 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CA9 Q16790 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL445508 0.89 FOLH1 (0.59) FOLH1ALDH1A1ALOX15TSHRCYP2C9
SCHEMBL30565103 0.89 FOLH1 (0.59) FOLH1ALDH1A1ALOX15TSHRCYP2C9
Hydrochloric Acid SCHEMBL3312470 0.87 FOLH1 (0.57) FOLH1ALDH1A1ALOX15TSHRCYP2C9
Phthalic Acid SCHEMBL31133630 0.80 ALDH1A1 (0.70) ALDH1A1ALOX15KDM4ECA12CA1
SCHEMBL3135339 0.74 FOLH1 (0.41) FOLH1ALDH1A1ALOX15TSHRCYP2C9
SCHEMBL8329762 0.74 FOLH1 (0.54) FOLH1ALDH1A1ALOX15TSHRCYP2C9
SCHEMBL3306402 0.73 FOLH1 (0.66) FOLH1ALDH1A1ALOX15TSHRTP53
SCHEMBL4448226 0.73 ALDH1A1 (0.46) FOLH1ALDH1A1ALOX15TSHRKDM4E
SCHEMBL7677994 0.73 POLB (0.43) FOLH1ALDH1A1ALOX15TSHRGAA
Salicylic Acid SCHEMBL3945202 0.73 ALDH1A1 (0.75) ALDH1A1ALOX15TSHRTP53HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7195835-B2 Proton conducting membrane for fuel cells UCHICAGO ARGONNE, LLC (US) 2007-03-27 US disclosed
US-20060094792-A1 Proton conducting membrane for fuel cells THE UNIVERSITY OF CHICAGO 2006-05-04 US disclosed
US-6977122-B2 Proton conducting membrane for fuel cells THE UNIVERSITY OF CHICAGO (US) 2005-12-20 US disclosed
US-20030035991-A1 Proton conducting membrane for fuel cells THE UNIVERSITY OF CHICAGO 2003-02-20 US disclosed