Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5440671 | 0.71 | MMP1 (0.36) | KCNA5KAT6AMMP2MMP9 | |
| SCHEMBL5484261 | 0.67 | CA2 (0.34) | CTSKCTSSMMP2MMP9 | |
| SCHEMBL5440673 | 0.66 | LARS1 (0.41) | CTSKCTSSMMP2MMP9 | |
| SCHEMBL6557593 | 0.63 | KEAP1 (0.41) | CTSKCTSSMMP2MMP9 | |
| SCHEMBL5440888 | 0.59 | GBA1 (0.63) | MMP2MMP9 | |
| SCHEMBL5471723 | 0.59 | PRMT1 (0.40) | CTSKCTSSMMP2MMP9 | |
| SCHEMBL740682 | 0.58 | KMT2A (0.51) | — | |
| SCHEMBL28880375 | 0.58 | KDM4E (0.42) | — | |
| SCHEMBL2969958 | 0.57 | MMP1 (0.59) | MMP2MMP9 | |
| SCHEMBL6401361 | 0.55 | MAPT (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196099-B2 | Compounds and compositions as cathepsin inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2007-03-27 | — | — | US | disclosed |