Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.40 |
| ▸ | MMP12 | P39900 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5440673 | 0.80 | LARS1 (0.41) | KEAP1CTSKCTSSMMP1MMP12 | |
| SCHEMBL5471723 | 0.78 | PRMT1 (0.40) | KEAP1CTSKCTSSMMP1MMP12 | |
| SCHEMBL7551628 | 0.75 | CTSS (0.49) | CTSKCTSS | |
| SCHEMBL2969958 | 0.70 | MMP1 (0.59) | KEAP1MMP1MMP12GAAPRMT1 | |
| SCHEMBL6557583 | 0.68 | SLC1A3 (0.37) | MMP1ALDH1A1MMP2MMP9MMP13 | |
| SCHEMBL13758640 | 0.67 | HSD11B1 (0.56) | KEAP1MMP1MMP12GAAALDH1A1 | |
| SCHEMBL6560207 | 0.67 | GRM7 (0.37) | MMP1ALDH1A1MMP2MMP9MMP13 | |
| SCHEMBL14378293 | 0.67 | MMP1 (0.51) | KEAP1MMP1MMP12GAAALDH1A1 | |
| SCHEMBL7366406 | 0.67 | ALDH1A1 (0.56) | KEAP1MMP1MMP12GAAALDH1A1 | |
| SCHEMBL359770 | 0.66 | MMP1 (0.79) | MMP1MMP12GAAALDH1A1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436255-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2004-07-14 | — | — | EP | claimed |
| WO-2003024924-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2003-03-27 | — | — | WO | claimed |