Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1042 | 0.97 | — | — | |
| SCHEMBL5719652 | 0.97 | TSHR (0.38) | — | |
| SCHEMBL13198079 | 0.97 | — | — | |
| Ammonia Solution, Strong SCHEMBL9221280 | 0.93 | — | — | |
| SCHEMBL28044604 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL7323438 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL3099736 | 0.90 | — | — | |
| Oxirane SCHEMBL28874614 | 0.83 | — | — | |
| Acetic Acid SCHEMBL28401154 | 0.83 | CHRM1 (0.46) | — | |
| Tert-Butanol SCHEMBL28284358 | 0.83 | TSHR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108697758-B | Medicament for effective control of acute and/or chronic pain and method of administration thereof | PVP实验室私人有限公司 | 2022-12-02 | — | — | CN | claimed |
| EP-3442557-B1 | A DRUG FORMULATION FOR USE IN THE EFFECTIVE CONTROL OF ACUTE AND/OR CHRONIC PAIN | PVP LABS PTE LTD (SG) | 2022-10-05 | — | — | EP | claimed |
| US-10357533-B2 | Drug for the effective control of acute and or chronic pain and a method for its administration | PVP LaBs PTE, Ltd. (SG) | 2019-07-23 | — | — | US | claimed |
| EP-3442557-A1 | A DRUG FOR THE EFFECTIVE CONTROL OF ACUTE AND/OR CHRONIC PAIN AND A METHOD FOR ITS ADMINISTRATION | PVP Labs PTE. Ltd. (SG) | 2019-02-20 | — | — | EP | claimed |
| US-20180221432-A1 | A drug for the effective control of acute and or chronic pain and a method for its administration | PVP LABS PTE. LTD (SG) | 2018-08-09 | — | — | US | claimed |
| WO-2017180064-A1 | A DRUG FOR THE EFFECTIVE CONTROL OF ACUTE AND/OR CHRONIC PAIN AND A METHOD FOR ITS ADMINISTRATION | PVP LABS PTE. LTD. (SG) | 2017-10-19 | — | — | WO | claimed |
| US-6680067-B2 | ANALGESIC IN ADMIXTURE WITH INJECTABLE OIL; NALBUPHINE FREE BASE OR A PHARMACEUTICALLY ACCEPTABLE SALT | Hu, Oliver Yoa-Pu (TW) | 2004-01-20 | — | — | US | claimed |
| US-20030113372-A1 | Controlled-release pharmaceutical preparation containing nalbuphine and a process for preparing the same | YUNG SHIN PHARMACEUTICALS CO., LTD. (TW) | 2003-06-19 | — | — | US | claimed |
| EP-3103446-B1 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | ZAKHAROV IVAN DMITRIEVICH (RU) | 2024-02-14 | — | — | EP | disclosed |
| CN-108697758-B | Medicament for effective control of acute and/or chronic pain and method of administration thereof | PVP实验室私人有限公司 | 2022-12-02 | — | — | CN | disclosed |
| EP-3442557-B1 | A DRUG FORMULATION FOR USE IN THE EFFECTIVE CONTROL OF ACUTE AND/OR CHRONIC PAIN | PVP LABS PTE LTD (SG) | 2022-10-05 | — | — | EP | disclosed |
| WO-2021076020-A2 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND PROPHYLAXIS OF INFECTIOUS INFLAMMATORY DISEASES | ГАПОНОВ, Андрей Михайлович | 2021-04-22 | — | — | WO | disclosed |
| US-10357533-B2 | Drug for the effective control of acute and or chronic pain and a method for its administration | PVP LaBs PTE, Ltd. (SG) | 2019-07-23 | — | — | US | disclosed |
| EP-3442557-A1 | A DRUG FOR THE EFFECTIVE CONTROL OF ACUTE AND/OR CHRONIC PAIN AND A METHOD FOR ITS ADMINISTRATION | PVP Labs PTE. Ltd. (SG) | 2019-02-20 | — | — | EP | disclosed |
| EP-1363603-B1 | METHOD FOR MAKING WATER SOLUBLE A POORLY WATER-SOLUBLE ANTISEPTIC | CLL PHARMA (FR) | 2005-06-01 | — | — | EP | disclosed |
| US-20040137053-A1 | Method for making water soluble a poorly water soluble antiseptic | CCL PHARMA (FR) | 2004-07-15 | — | — | US | disclosed |
| US-6680067-B2 | ANALGESIC IN ADMIXTURE WITH INJECTABLE OIL; NALBUPHINE FREE BASE OR A PHARMACEUTICALLY ACCEPTABLE SALT | Hu, Oliver Yoa-Pu (TW) | 2004-01-20 | — | — | US | disclosed |
| EP-1363603-A1 | METHOD FOR MAKING WATER SOLUBLE A POORLY WATER-SOLUBLE ANTISEPTIC | CLL Pharma (FR) | 2003-11-26 | — | — | EP | disclosed |
| US-20030113372-A1 | Controlled-release pharmaceutical preparation containing nalbuphine and a process for preparing the same | YUNG SHIN PHARMACEUTICALS CO., LTD. (TW) | 2003-06-19 | — | — | US | disclosed |
| WO-2002069931-A1 | METHOD FOR MAKING WATER SOLUBLE A POORLY WATER-SOLUBLE ANTISEPTIC | CLL PHARMA (FR) | 2002-09-12 | — | — | WO | disclosed |