Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.43 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10982297 | 0.88 | ATM (0.50) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL15270328 | 0.86 | LMNA (0.52) | LMNAALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL5362455 | 0.86 | LMNA (0.52) | LMNAALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL2656422 | 0.84 | LMNA (0.53) | LMNAALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL2648717 | 0.84 | LMNA (0.53) | LMNAALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL29999641 | 0.83 | POLB (0.51) | LMNAALDH1A1MAPTSMN1; SMN2FFAR1 | |
| SCHEMBL3533309 | 0.83 | POLB (0.51) | LMNAALDH1A1MAPTSMN1; SMN2FFAR1 | |
| SCHEMBL14565801 | 0.82 | LMNA (0.52) | LMNAALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL29988362 | 0.82 | ALDH1A1 (0.53) | LMNAALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL2340873 | 0.82 | ALDH1A1 (0.53) | LMNAALDH1A1MEN1KMT2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180222871-A1 | METHOD FOR PREPARING SUBSTITUTED 3-(2-ANILINO-1-CYCLOHEXYL-1H-BENZIMIDAZOL-5-YL)PROPANOIC ACID DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-08-09 | — | — | US | claimed |
| EP-3328838-A1 | METHOD FOR PREPARING SUBSTITUTED 3-(2-ANILINO-1-CYCLOHEXYL-1H-BENZIMIDAZOL-5-YL)PROPANOIC ACID DERIVATIVES | Bayer Pharma Aktiengesellschaft (DE) | 2018-06-06 | — | — | EP | claimed |
| WO-2017017046-A1 | METHOD FOR PREPARING SUBSTITUTED 3-(2-ANILINO-1-CYCLOHEXYL-1H-BENZIMIDAZOL-5-YL)PROPANOIC ACID DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-02-02 | — | — | WO | claimed |
| CN-107848985-B | Process for preparing substituted 3- (2-anilino-1-cyclohexyl-1H-benzimidazol-5-yl) propionic acid derivatives | 德国癌症研究公共权益基金会 | 2021-09-03 | — | — | CN | disclosed |
| US-10703727-B2 | Method for preparing substituted 3-(2-anilino-1-cyclohexyl-1H-benzimidazol-5-yl)propanoic acid derivatives | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-07-07 | — | — | US | disclosed |
| US-10703727-B2 | Method for preparing substituted 3-(2-anilino-1-cyclohexyl-1H-benzimidazol-5-yl)propanoic acid derivatives | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-07-07 | — | — | US | disclosed |
| US-10442772-B2 | Benzimidazol-2-amines as mIDH1 inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-10-15 | — | — | US | disclosed |
| EP-3105209-B1 | BENZIMIDAZOL-2-AMINES AS MIDH1 INHIBITORS | Bayer Pharma AG (DE) | 2019-08-21 | — | — | EP | disclosed |
| US-20180222871-A1 | METHOD FOR PREPARING SUBSTITUTED 3-(2-ANILINO-1-CYCLOHEXYL-1H-BENZIMIDAZOL-5-YL)PROPANOIC ACID DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-08-09 | — | — | US | disclosed |
| US-20180222871-A1 | METHOD FOR PREPARING SUBSTITUTED 3-(2-ANILINO-1-CYCLOHEXYL-1H-BENZIMIDAZOL-5-YL)PROPANOIC ACID DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-08-09 | — | — | US | disclosed |
| EP-3328838-A1 | METHOD FOR PREPARING SUBSTITUTED 3-(2-ANILINO-1-CYCLOHEXYL-1H-BENZIMIDAZOL-5-YL)PROPANOIC ACID DERIVATIVES | Bayer Pharma Aktiengesellschaft (DE) | 2018-06-06 | — | — | EP | disclosed |
| US-9957235-B2 | Benzimidazol-2-amines as mIDH1 inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-01 | — | — | US | disclosed |
| US-20170197921-A1 | BENZIMIDAZOL-2-AMINES AS MIDH1 INHIBITORS | DEUTSCHES KREBSFORSCHUNGSZENTRUM, STIFTUNG DES ÖFFENTLICHEN RECHTS (DE) | 2017-07-13 | — | — | US | disclosed |
| WO-2017017046-A1 | METHOD FOR PREPARING SUBSTITUTED 3-(2-ANILINO-1-CYCLOHEXYL-1H-BENZIMIDAZOL-5-YL)PROPANOIC ACID DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-02-02 | — | — | WO | disclosed |
| EP-3105209-A1 | BENZIMIDAZOL-2-AMINES AS MIDH1 INHIBITORS | Bayer Pharma Aktiengesellschaft (DE) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015121210-A1 | BENZIMIDAZOL-2-AMINES AS MIDH1 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-08-20 | — | — | WO | disclosed |
| EP-1663988-B1 | BENZYL-BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-04-16 | — | — | EP | disclosed |
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | MERCK PATENT GMBH (DE) | 2007-03-22 | — | — | US | disclosed |
| EP-1663988-A1 | BENZYL-BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005028448-A1 | BENZYL-BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703727-B2 | Method for preparing substituted 3-(2-anilino-1-cyclohexyl-1H-benzimidazol-5-yl)propanoic acid derivatives | HCAR3, AKR1C3, HCAR2 | LMNA 786/4885ALDH1A1 220/4885MEN1 1638/4885 |
| US-20070066606-A1 | Benzylbenzimidazolyl derivatives | TIE1, KDR, FLT1 | LMNA 3932/4885ALDH1A1 745/4885MEN1 2354/4885 |
| US-20180222871-A1 | METHOD FOR PREPARING SUBSTITUTED 3-(2-ANILINO-1-CYCLOHEXYL-1H-BENZIMIDAZOL-5-YL)PROPANOIC ACID DERIVATIVES | HCAR3, AKR1C3, HCAR2 | LMNA 786/4885ALDH1A1 220/4885MEN1 1638/4885 |
| US-10442772-B2 | Benzimidazol-2-amines as mIDH1 inhibitors | HRH1, HRH2, HRH3 | LMNA 1895/4885ALDH1A1 741/4885MEN1 25/4885 |
| US-20170197921-A1 | BENZIMIDAZOL-2-AMINES AS MIDH1 INHIBITORS | HRH1, HRH2, HRH3 | LMNA 1895/4885ALDH1A1 741/4885MEN1 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.