Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.52 |
| ▸ | ACLY | P53396 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 10/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | FPR3 | P25089 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | APLNR | P35414 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL344080 | 0.87 | MET (0.52) | METACLYHTR6HTR2CHTR7 | |
| SCHEMBL1422419 | 0.77 | DYRK1A (0.53) | METACLYHTR6HTR2CHTR7 | |
| SCHEMBL1743494 | 0.74 | MET (0.51) | METACLYHTR6HTR2CHTR7 | |
| SCHEMBL14468673 | 0.72 | DYRK1A (0.50) | METACLYHTR6HTR2CHTR7 | |
| SCHEMBL1423064 | 0.71 | TDP1 (0.44) | METACLYHTR6HTR2CHTR7 | |
| SCHEMBL14447519 | 0.71 | MET (0.51) | METACLYHTR6HTR2CHTR7 | |
| SCHEMBL13211040 | 0.71 | HTR6 (0.52) | METACLYHTR6HTR2CDYRK1A | |
| SCHEMBL8198585 | 0.71 | MET (0.48) | METACLYHTR6HTR2CHTR7 | |
| SCHEMBL1422160 | 0.69 | ACLY (0.52) | METACLYHTR6HTR2CHTR7 | |
| SCHEMBL1422633 | 0.68 | ACLY (0.58) | METACLYHTR6HTR2CCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203121-A1 | SUBSTITUTED INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A (ES) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203121-A1 | SUBSTITUTED INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | HTR6, TPH1, TPH2 | MET 1006/4885ACLY 3959/4885HTR6 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.