SCHEMBL5484876

SCHEMBL5484876

COc1ccc(C(C)[Si](Cl)(Cl)Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.50
TSHR P16473 1/20 0.50
MAPK1 P28482 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
CA12 O43570 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
AOC3 Q16853 1/20 0.43
SLC2A1 P11166 1/20 0.42
GAA P10253 2/20 0.42
KDM4E B2RXH2 1/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
HTT P42858 1/20 0.42
ACHE P22303 2/20 0.42
CYP1A2 P05177 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17442483 0.83 ESR1 (0.39) ALDH1A1GAAHTTESR2
SCHEMBL5804645 0.77 CA1 (0.46) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL7913947 0.76 ALDH1A1 (0.34) ALDH1A1GAALMNAESR2
SCHEMBL16335309 0.75 CYP17A1 (0.45) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL919843 0.75 LMNA (0.50) ALDH1A1TSHRGAAKDM4ELMNA
SCHEMBL365643 0.75 TDP1 (0.56) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL839864 0.75 CHRNA7 (0.41) ALDH1A1TDP1CA1CA2CA7
SCHEMBL5484844 0.75 ADRB2 (0.52) TSHRMAPK1TDP1AOC3LMNA
SCHEMBL84040 0.74 RAB9A (0.62) ALDH1A1TSHRMAPK1TDP1L3MBTL1
SCHEMBL834546 0.74 CA1 (0.61) ALDH1A1TSHRMAPK1TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291747-B2 Silicon compounds and process for preparation thereof CHISSO CORPORATION (JP) 2007-11-06 US disclosed
US-20040143081-A1 Novel silicon compounds and process for preparation thereof JNC CORPORATION (JP) 2004-07-22 US disclosed
EP-0731105-B1 Optically active tertiary phosphine compounds, transition metal complexes comprising the same as ligands and process for preparing optically active organic silicon compounds using said transition metal complexes SUMITOMO CHEMICAL CO (JP) 2001-12-05 EP disclosed
US-5612170-A SILICONE, PHOTO ACID GENERATOR, DISSOLUTION INHIBITOR SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-03-18 US disclosed
EP-0731105-A1 Optically active tertiary phosphine compounds, transition metal complexes comprising the same as ligands and process for preparing optically active organic silicon compounds using said transition metal complexes SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-09-11 EP disclosed