Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | POLB | P06746 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114219 | 0.78 | ALDH1A1 (0.48) | ALDH1A1TDP1HPGDHSD17B10THRB | |
| SCHEMBL9537233 | 0.72 | ALOX5 (0.45) | ALDH1A1KDM4EKMT2ATDP1HPGD | |
| SCHEMBL10624403 | 0.72 | ALDH1A1 (0.37) | ALDH1A1TDP1HPGDHSD17B10TSHR | |
| SCHEMBL134135 | 0.71 | ALDH1A1 (0.40) | ALDH1A1KDM4EKMT2AESR1TDP1 | |
| SCHEMBL578393 | 0.69 | ALDH1A1 (0.39) | ALDH1A1KDM4EPOLBTDP1HPGD | |
| SCHEMBL157996 | 0.69 | KDM4E (0.46) | ALDH1A1KDM4EPOLBKMT2AESR1 | |
| SCHEMBL14782750 | 0.69 | KDM4E (0.36) | ALDH1A1KDM4EPOLBKMT2ATDP1 | |
| SCHEMBL4558087 | 0.68 | ALDH1A1 (0.39) | ALDH1A1KDM4EPOLBKMT2ATDP1 | |
| SCHEMBL6537032 | 0.67 | ALDH1A1 (0.40) | ALDH1A1KDM4ETDP1HPGDHSD17B10 | |
| SCHEMBL20774056 | 0.67 | ALDH1A1 (0.45) | ALDH1A1POLBTDP1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838288-A1 | THERAPEUTIC MATERIALS AND METHODS | ARIAD GENE THERAPEUTICS, INC. (US) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006069038-A1 | THERAPEUTIC MATERIALS AND METHODS | ARIAD GENE THERAPEUTICS, INC. (US) | 2006-06-29 | — | — | WO | disclosed |