SCHEMBL157996

SCHEMBL157996

c1coc(-c2cccc3ccccc23)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.46
KMT2A Q03164 5/20 0.46
HSD17B10 Q99714 4/20 0.46
MEN1 O00255 3/20 0.46
MAPT P10636 3/20 0.46
NPC1 O15118 1/20 0.46
TP53 P04637 1/20 0.46
GAA P10253 1/20 0.46
NFKB1 P19838 1/20 0.46
CASP3 P42574 1/20 0.46
RAB9A P51151 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
SENP8 Q96LD8 1/20 0.46
SENP7 Q9BQF6 1/20 0.46
SENP6 Q9GZR1 1/20 0.46
ALDH1A1 P00352 5/20 0.45
POLB P06746 4/20 0.45
ESR1 P03372 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26259566 0.89 POLB (0.48) KDM4EKMT2AHSD17B10MEN1MAPT
SCHEMBL26259380 0.84 KDM4E (0.48) KDM4EKMT2AHSD17B10MEN1MAPT
SCHEMBL20740270 0.83 TDP1 (0.44) KDM4EKMT2AHSD17B10MEN1MAPT
SCHEMBL30386272 0.83 TDP1 (0.44) KDM4EKMT2AHSD17B10MEN1MAPT
SCHEMBL24309030 0.82 TDP1 (0.49) KDM4EKMT2AHSD17B10MEN1MAPT
SCHEMBL26259720 0.78 ALDH1A1 (0.54) KDM4EKMT2AHSD17B10MEN1MAPT
SCHEMBL19662084 0.78 TDP1 (0.47) KDM4EKMT2AHSD17B10MEN1MAPT
SCHEMBL1310537 0.77 KMT2A (0.62) KDM4EKMT2AHSD17B10MEN1MAPT
SCHEMBL22124455 0.76 KDM4E (0.41) KDM4EKMT2AHSD17B10MEN1MAPT
SCHEMBL16398511 0.75 ALDH1A1 (0.42) KDM4EKMT2AHSD17B10MEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112521531-A Olefin polymerization catalyst component, preparation method thereof, olefin polymerization catalyst and polymerization method 中国石油天然气股份有限公司 2021-03-19 CN claimed
US-20130123266-A1 TREATMENT OF A PATHOLOGY LINKED TO AN EXCESSIVE EFFECT OF TNF WITH A BENZENE SULPHONAMIDE COMPOUND VAX-CONSULTING (FR) 2013-05-16 US claimed
US-20230287262-A1 PHOTON UPCONVERSION COMPOSITION, FILM, METHOD FOR CONVERTING VISIBLE LIGHT INTO ULTRAVIOLET LIGHT, AND COMPOUND KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) 2023-09-14 US disclosed
CN-112521531-B Olefin polymerization catalyst component, preparation method thereof, olefin polymerization catalyst and polymerization method 中国石油天然气股份有限公司 2022-12-02 CN disclosed
US-11370967-B2 Light emitting apparatus and electronic device comprising light emitting apparatus DOW GLOBAL TECHNOLOGIES LLC (US) 2022-06-28 US disclosed
US-11289654-B2 Polymers containing furanyl crosslinkable groups and uses thereof GUANGZHOU CHINARAY OPTOELECTRONIC MATERIALS LTD. (CN) 2022-03-29 US disclosed
EP-3465332-B1 LIGHT EMITTING APPARATUS AND ELECTRONIC DEVICE COMPRISING THE SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2021-07-21 EP disclosed
US-20210186927-A1 COMBINATION PRODUCT FOR THE INDUCTION AND/OR MAINTENANCE OF GENERAL ANESTHESIA TERRAN BIOSCIENCES, INC. 2021-06-24 US disclosed
CN-112521531-A Olefin polymerization catalyst component, preparation method thereof, olefin polymerization catalyst and polymerization method 中国石油天然气股份有限公司 2021-03-19 CN disclosed
US-20200317999-A1 LIGHT EMITTING APPARATUS AND ELECTRONIC DEVICE COMPRISING THE SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2020-10-08 US disclosed
US-20200299573-A1 COMPOSITE COMPRISING SEMICONDUCTOR NANOCRYSTALS AND METHOD OF PREPARING THE SAME ROHM AND HAAS ELECTRONIC MATERIALS LLC 2020-09-24 US disclosed
US-5489505-A ON A SUPPORT ATLEAST ONE SILVER HALIDE EMULSION AND ATLEAST ONE METHINE DYE; STORAGE STABILITY AND HIGH SENSITIVITY FUJI PHOTO FILM CO., LTD. (JP) 1996-02-06 US disclosed
US-5459029-A Photographic element hardened with imidazolium hardeners E. I. DU PONT DE NEMOURS AND COMPANY (US) 1995-10-17 US disclosed
US-5433896-A FLUORESCENT MOLECULAR PROBES, INC. (US) 1995-07-18 US disclosed
US-5378842-A Aminocarbonyl derivatives E. I. DU PONT DE NEMOURS AND COMPANY (US) 1995-01-03 US disclosed
WO-1993018016-A1 FUNGICIDAL OXAZOLIDINONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-09-16 WO disclosed
EP-0397364-B1 HETEROCYCLIC GUANIDINES AS 5HT 3 ANTAGONISTS PFIZER INC. (US) 1993-07-28 EP disclosed
US-5035984-A Computer output images, nucleating agent FUJI PHOTO FILM CO., LTD. (JP) 1991-07-30 US disclosed
EP-0397364-A1 Heterocyclic guanidines AS 5HT 3 Antagonists PFIZER INC. (US) 1990-11-14 EP disclosed
US-4963689-A ANTIEMETICS, ANALGESICS, GASTROINTESTINAL DISORDERS, SCHIZOPHRENIA PFIZER INC. (US) 1990-10-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210186927-A1 COMBINATION PRODUCT FOR THE INDUCTION AND/OR MAINTENANCE OF GENERAL ANESTHESIA OPRK1, OPRD1, GABRD KDM4E 1235/4885KMT2A 733/4885HSD17B10 3880/4885
US-20130123266-A1 TREATMENT OF A PATHOLOGY LINKED TO AN EXCESSIVE EFFECT OF TNF WITH A BENZENE SULPHONAMIDE COMPOUND TNF, TNFRSF1A, TRAF6 KDM4E 3466/4885KMT2A 3647/4885HSD17B10 1595/4885
US-20200317999-A1 LIGHT EMITTING APPARATUS AND ELECTRONIC DEVICE COMPRISING THE SAME CRY1, CRY2, LAGE3 KDM4E 2596/4885KMT2A 1072/4885HSD17B10 3512/4885
US-20230287262-A1 PHOTON UPCONVERSION COMPOSITION, FILM, METHOD FOR CONVERTING VISIBLE LIGHT INTO ULTRAVIOLET LIGHT, AND COMPOUND NUDC, CCNL2, SPIN3 KDM4E 1663/4885KMT2A 3312/4885HSD17B10 4034/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.