SCHEMBL5486401

SCHEMBL5486401

COc1ccccc1C(c1ccccc1)(c1ccccc1OC)C(O)[C@H]1O[C@@H](n2cc(F)c(=O)[nH]c2=O)C[C@@H]1O

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
TYMS P04818 3/20 0.44
TK1 P04183 4/20 0.39
ALOX12 P18054 1/20 0.38
ADRA1A P35348 1/20 0.38
HSP90AA1 P07900 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20636770 0.96 LMNA (0.42) LMNASMN1; SMN2TYMSTK1ALOX12
SCHEMBL2027057 0.91 LMNA (0.49) LMNASMN1; SMN2TYMSTK1ALOX12
SCHEMBL1687292 0.91 TK1 (0.51) TK1
SCHEMBL5086839 0.90 TK1 (0.46) TYMSTK1
SCHEMBL20840413 0.89 TK1 (0.40) TYMSTK1
SCHEMBL8892071 0.89 TK1 (0.40) TYMSTK1
SCHEMBL9495888 0.89 LMNA (0.54) LMNASMN1; SMN2TYMSTK1ALOX12
SCHEMBL5486404 0.88 LMNA (0.47) LMNASMN1; SMN2TYMSTK1HSP90AA1
SCHEMBL2030339 0.88 TK1 (0.38) TYMSTK1
SCHEMBL7602616 0.87 TK1 (0.42) TYMSTK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11674135-B2 DNA-encoded libraries having encoding oligonucleotide linkages not readable by polymerases X-CHEM, INC. (US) 2023-06-13 US disclosed
US-10865409-B2 Methods for tagging DNA-encoded libraries X-CHEM, INC. (US) 2020-12-15 US disclosed
US-20200223893-A1 THERAPEUTIC NANOCONJUGATES AND USES THEREOF CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED (ES) 2020-07-16 US disclosed
EP-3651809-A1 THERAPEUTIC NANOCONJUGATES AND USES THEREOF Universitat Autónoma De Barcelona (UAB) (ES) 2020-05-20 EP disclosed
US-20200143903-A1 METHODS FOR IDENTIFYING COMPOUNDS MIDCAP FINANCIAL TRUST 2020-05-07 US disclosed
WO-2019012157-A1 THERAPEUTIC NANOCONJUGATES AND USES THEREOF UNIVERSITAT AUTÒNOMA DE BARCELONA (UAB) (ES) 2019-01-17 WO disclosed
EP-3427756-A1 THERAPEUTIC NANOCONJUGATES AND USES THEREOF Universidad Autónoma De Barcelona (UAB) (ES) 2019-01-16 EP disclosed
EP-2872680-B1 DNA-ENCODED LIBRARIES HAVING ENCODING OLIGONUCLEOTIDE LINKAGES NOT READABLE BY POLYMERASES X CHEM INC (US) 2018-04-04 EP disclosed
US-20150211002-A1 DNA-ENCODED LIBRARIES HAVING ENCODING OLIGONUCLEOTIDE LINKAGES NOT READABLE BY POLYMERASES PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC 2015-07-30 US disclosed
CN-104685115-A DNA coding libraries with polymerase-unreadable coding oligonucleotide linkages CHEM INC X 2015-06-03 CN disclosed
US-20140315762-A1 METHODS FOR TAGGING DNA-ENCODED LIBRARIES X-CHEM, INC. (US) 2014-10-23 US disclosed
CN-103998658-A Methods for tagging DNA-encoded libraries CHEM INC X 2014-08-20 CN disclosed
US-7262177-B2 Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and methods of use CELL WORKS THERAPEUTICS, INC. (US) 2007-08-28 US disclosed
US-20050250679-A1 Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and methods of use Cell Works Therapeutics, Inc., Delaware corporations 2005-11-10 US disclosed
US-6906182-B2 Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use CELL WORKS THERAPEUTICS, INC. (US) 2005-06-14 US disclosed
WO-2002043771-A9 CONJUGATES OF GLYCOSYLATED/GALACTOSYLATED PEPTIDE CELL WORKS INC (US) 2004-04-29 WO disclosed
EP-1355672-A2 CONJUGATES OF GLYCOSYLATED/GALACTOSYLATED PEPTIDE, BIFUNCTIONAL LINKER, AND NUCLEOTIDIC MONOMERS/POLYMERS, AND RELATED COMPOSITIONS AND METHODS OF USE Cell Works Inc. (US) 2003-10-29 EP disclosed
US-20030032584-A1 Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use CELL WORKS INC. (US) 2003-02-13 US disclosed
WO-2002043771-A2 CONJUGATES OF GLYCOSYLATED/GALACTOSYLATED PEPTIDE CELL WORKS INC. (US) 2002-06-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030032584-A1 Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use LNPEP, B3GAT3, GALNT1 LMNA 431/4885SMN1; SMN2 3373/4885TYMS 145/4885
US-20050250679-A1 Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and methods of use LNPEP, B3GAT3, GALNT1 LMNA 449/4885SMN1; SMN2 3310/4885TYMS 161/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.