Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23367388 | 0.83 | P2RX7 (0.42) | P2RX7NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL11691729 | 0.81 | P2RX7 (0.42) | PKMP2RX7NPC1RAB9AALDH1A1 | |
| SCHEMBL9814514 | 0.81 | P2RX7 (0.62) | PKMP2RX7NPC1RAB9AALDH1A1 | |
| SCHEMBL9215564 | 0.73 | MAPK1 (0.36) | SMN1; SMN2MEN1KMT2ATERT | |
| SCHEMBL15577228 | 0.73 | PKM (0.56) | PKMNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL5490040 | 0.72 | PKM (0.44) | PKMNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL12442424 | 0.71 | P2RX7 (0.42) | PKMP2RX7NPC1RAB9AALDH1A1 | |
| SCHEMBL11696173 | 0.71 | P2RX7 (0.42) | PKMP2RX7NPC1RAB9AALDH1A1 | |
| SCHEMBL2895448 | 0.71 | GRM5 (0.45) | PKMNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL5487652 | 0.71 | PKM (0.47) | PKMNPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185178-A1 | Triazole compounds and their use as metabotropic glutamate receptor antagonists | AATRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
| EP-1720860-A1 | TRIAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2006-11-15 | — | — | EP | disclosed |
| US-20060019997-A1 | Triazole compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB | 2006-01-26 | — | — | US | disclosed |
| WO-2005080379-A1 | TRIAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (US) | 2005-09-01 | — | — | WO | disclosed |
| US-3985765-A | ANTIINFLAMMATORY OR ANTIPYRETIC ACTIVITY | MILES LABORATORIES, INC. (US) | 1976-10-12 | — | — | US | disclosed |
| US-3948932-A | ANTIINFLAMMATORY, ANTIPYRETIC | MILES LABORATORIES, INC. (US) | 1976-04-06 | — | — | US | disclosed |
| US-3948929-A | ANTIINFLAMMATORY, ANTIPYRETIC | MILES LABORATORIES, INC. (US) | 1976-04-06 | — | — | US | disclosed |
| US-3948930-A | ANTIINFLAMMATORY, ANTIPYRETIC | MILES LABORATORIES, INC. (US) | 1976-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019997-A1 | Triazole compounds and their use as metabotropic glutamate receptor antagonists | GRM3, GRIN3A, GRM1 | PKM 1538/4885P2RX7 32/4885NPC1 1874/4885 |
| US-20070185178-A1 | Triazole compounds and their use as metabotropic glutamate receptor antagonists | GRM5, GRM3, GRIK5 | PKM 990/4885P2RX7 39/4885NPC1 2690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.