Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5487008 | 0.83 | PKM (0.43) | P2RX7NPC1RAB9AMGLLALDH1A1 | |
| SCHEMBL11696173 | 0.80 | P2RX7 (0.42) | P2RX7NPC1RAB9AMGLLALDH1A1 | |
| SCHEMBL9814514 | 0.80 | P2RX7 (0.62) | P2RX7NPC1RAB9AALDH1A1ADORA2A | |
| SCHEMBL23385108 | 0.74 | RPA1 (0.44) | NPC1RAB9APAX8HSP90AA1MGLL | |
| SCHEMBL15578745 | 0.74 | RPA1 (0.53) | NPC1RAB9APAX8HSP90AA1MGLL | |
| SCHEMBL26251816 | 0.73 | MAPK14 (0.42) | NPC1RAB9APAX8HSP90AA1MGLL | |
| SCHEMBL4251316 | 0.73 | MEN1 (0.54) | P2RX7NPC1RAB9APAX8HSP90AA1 | |
| SCHEMBL2896761 | 0.72 | GRM5 (0.44) | NPC1RAB9APAX8HSP90AA1MGLL | |
| SCHEMBL28434913 | 0.72 | RAB9A (0.48) | NPC1RAB9AALDH1A1L3MBTL1ADORA2A | |
| SCHEMBL23367361 | 0.71 | P2RX7 (0.37) | P2RX7MGLLALDH1A1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021094434-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2021-05-20 | — | — | WO | disclosed |
| EP-3822265-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | Bayer AG (DE) | 2021-05-19 | — | — | EP | disclosed |