SCHEMBL5488906

SCHEMBL5488906

Clc1ccc(Cl)c(C[Si](Cl)(Cl)Cl)c1Cl

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.35
CYP3A4 P08684 1/20 0.33
MAPK1 P28482 1/20 0.33
TAAR1 Q96RJ0 1/20 0.30
NOTUM Q6P988 1/20 0.30
PNMT P11086 1/20 0.30
CYP2A6 P11509 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5486140 0.82 TAAR1 (0.46) TAAR1PNMTCYP2A6
SCHEMBL5488068 0.73 CYP3A4 (0.46) ARCYP3A4MAPK1
SCHEMBL5493318 0.73 AR (0.32) ARTAAR1
SCHEMBL5494630 0.72 ALDH1A1 (0.41) ARCYP3A4MAPK1
SCHEMBL5487912 0.72 AR (0.31) AR
SCHEMBL10600544 0.70 CYP3A4 (0.38) ARCYP3A4MAPK1TAAR1PNMT
SCHEMBL5490681 0.69
SCHEMBL900758 0.69 CYP3A4 (0.36) ARCYP3A4MAPK1TAAR1PNMT
SCHEMBL17552714 0.69 CYP3A4 (0.36) ARCYP3A4MAPK1TAAR1PNMT
SCHEMBL859436 0.69 CYP3A4 (0.36) ARCYP3A4MAPK1TAAR1PNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291747-B2 Silicon compounds and process for preparation thereof CHISSO CORPORATION (JP) 2007-11-06 US disclosed
US-20040143081-A1 Novel silicon compounds and process for preparation thereof JNC CORPORATION (JP) 2004-07-22 US disclosed