Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5488744 | 0.83 | RAB9A (0.46) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5489215 | 0.80 | RORC (0.43) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5489352 | 0.77 | CCR2 (0.61) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL5492511 | 0.76 | KMT2A (0.49) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL6180094 | 0.75 | ALDH1A1 (0.50) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5492650 | 0.74 | ALDH1A1 (0.49) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5495759 | 0.72 | CCR2 (0.61) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5492667 | 0.72 | CCR2 (0.64) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5492637 | 0.72 | CCR2 (0.46) | MAPTRAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5487911 | 0.72 | KDR (0.57) | MAPTRAB9ALMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297696-B2 | Antagonists of MCP-1 function and methods of use thereof | TELIK, INC. (US) | 2007-11-20 | — | — | US | claimed |