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Flomoxef

Flomoxef

SCHEMBL5490277

CO[C@@]1(NC(=O)CSC(F)F)C(=O)N2C(C(=O)O)=C(CSc3nnnn3CCO)CO[C@@H]21.Cc1onc(-c2c(F)cccc2Cl)c1C(=O)N[C@@H]1C(=O)N2[C@@H]1SC(C)(C)[C@@H]2C(=O)O.[NaH].[NaH]

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Flomoxef. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ ABCB11 O95342 3/20 0.52
▸ CYP1A2 P05177 1/20 0.52
▸ LMNA P02545 2/20 0.46
▸ HPGD P15428 2/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ TDP1 Q9NUW8 1/20 0.42
▸ SLCO1B3 Q9NPD5 1/20 0.41
▸ SLCO1B1 Q9Y6L6 1/20 0.41
▸ CMA1 P23946 8/20 0.41
▸ PTGS1 P23219 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flomoxef SCHEMBL2563269 1.00 ABCB11 (0.53) ABCB11CYP1A2LMNAHPGDMEN1
Flomoxef SCHEMBL65125 0.78 PTGS1 (0.57) TDP1CMA1PTGS1
Flomoxef SCHEMBL49438 0.78 PTGS1 (0.57) TDP1CMA1PTGS1
Flomoxef SCHEMBL14423926 0.78 PTGS1 (0.57) TDP1CMA1PTGS1
Flomoxef SCHEMBL27661462 0.77 PTGS1 (0.57) TDP1CMA1PTGS1
Floxacillin SCHEMBL855083 0.73 ABCB11 (0.98) ABCB11CYP1A2LMNAHPGDMEN1
Floxacillin SCHEMBL2636814 0.72 ABCB11 (0.97) ABCB11CYP1A2LMNAHPGDMEN1
Floxacillin SCHEMBL3823 0.72 ABCB11 (1.00) ABCB11CYP1A2LMNAHPGDMEN1
Floxacillin SCHEMBL14126462 0.72 ABCB11 (1.00) ABCB11CYP1A2LMNAHPGDMEN1
Floxacillin SCHEMBL22651560 0.72 ABCB11 (1.00) ABCB11CYP1A2LMNAHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007062198-A1 METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY ADVANCED CELL TECHNOLOGY, INC. (US) 2007-05-31 — — WO disclosed