Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 1/20 | 0.39 |
| ▸ | ADH1C | P00326 | 1/20 | 0.39 |
| ▸ | ADH1A | P07327 | 1/20 | 0.39 |
| ▸ | ADH7 | P40394 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | ACP3 | P15309 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.34 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15898195 | 0.71 | CTSC (0.38) | SMN1; SMN2SIGMAR1L3MBTL1LMNACTSS | |
| SCHEMBL8297976 | 0.71 | EPHX2 (0.47) | SMN1; SMN2MEN1KMT2AHPGDTSHR | |
| SCHEMBL7862909 | 0.70 | PPID (0.43) | SMN1; SMN2MEN1KMT2ATDP1ATM | |
| SCHEMBL5497103 | 0.70 | KDM4E (0.36) | SMN1; SMN2SIGMAR1MEN1KMT2AATM | |
| SCHEMBL24581622 | 0.69 | ALDH1A1 (0.34) | SMN1; SMN2SIGMAR1MEN1KMT2AL3MBTL1 | |
| SCHEMBL19185595 | 0.68 | SIGMAR1 (0.42) | SMN1; SMN2SIGMAR1MCL1ACP3MEN1 | |
| SCHEMBL19185547 | 0.68 | SIGMAR1 (0.48) | ADH1BADH1CADH1AADH7SMN1; SMN2 | |
| SCHEMBL24323636 | 0.66 | SIGMAR1 (0.40) | SMN1; SMN2SIGMAR1MCL1CTSSKDM4E | |
| SCHEMBL3338932 | 0.65 | SIGMAR1 (0.55) | SMN1; SMN2SIGMAR1MCL1MEN1KMT2A | |
| SCHEMBL13266485 | 0.64 | SMN1; SMN2 (0.50) | SMN1; SMN2SIGMAR1ACP3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1310487-B1 | PROCESSES FOR PREPARATION OF BICYCLIC COMPOUNDS AND INTERMEDIATES THEREFOR | DAIICHI SEIYAKU CO (JP) | 2007-01-03 | — | — | EP | disclosed |
| US-7074837-B2 | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| US-20050272797-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI PHARMACEUTICAL CO., LTD. | 2005-12-08 | — | — | US | disclosed |
| US-20040019223-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-01-29 | — | — | US | disclosed |
| EP-1310487-A1 | PROCESSES FOR PREPARATION OF BICYCLIC COMPOUNDS AND INTERMEDIATES THEREFOR | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019223-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DCXR, CYP51A1, WEE1 | ADH1B 718/4885ADH1C 2663/4885ADH1A 2699/4885 |
| US-20050272797-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DCXR, WEE1, CYP51A1 | ADH1B 719/4885ADH1C 2874/4885ADH1A 2883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.