Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 3/20 | 0.64 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | LAP3 | P28838 | 4/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.41 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL18281512 | 0.98 | SPPL2A (0.61) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4373559 | 0.85 | SPPL2A (0.76) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4911140 | 0.85 | SPPL2A (0.76) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1051190 | 0.85 | SPPL2A (0.74) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9605440 | 0.85 | SPPL2A (0.74) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23129692 | 0.85 | SPPL2A (0.74) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL608142 | 0.85 | SPPL2A (0.74) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10031792 | 0.85 | SPPL2A (0.74) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL14637729 | 0.84 | SPPL2A (0.73) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL14636197 | 0.84 | SPPL2A (0.73) | SPPL2APSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060642-A1 | Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate | JANSSEN SCIENCES IRELAND UC (IE) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060642-A1 | Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate | HPD, HTR3C, HAAO | SPPL2A 1288/4885PSEN1 508/4885PSEN2 1208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.