SCHEMBL5491058

SCHEMBL5491058

N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)O

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ ALPI P09923 1/20 0.62
▸ PKM P14618 1/20 0.62
▸ PTGS1 P23219 1/20 0.62
▸ XIAP P98170 1/20 0.62
▸ SLC7A5 Q01650 1/20 0.62
▸ SLC15A1 P46059 2/20 0.57
▸ LAP3 P28838 7/20 0.56
▸ ANPEP P15144 2/20 0.56
▸ RNPEP Q9H4A4 1/20 0.56
▸ DNPEP Q9ULA0 1/20 0.56
▸ SLC1A3 P43003 2/20 0.56
▸ SLC1A2 P43004 2/20 0.56
▸ SLC1A1 P43005 2/20 0.56
▸ CYP1A2 P05177 1/20 0.55
▸ LTA4H P09960 2/20 0.55
▸ SRR Q9GZT4 2/20 0.52
▸ EPHX1 P07099 1/20 0.50
▸ CPA1 P15085 1/20 0.48
▸ CPA3 P15088 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2201323 1.00 ALPI (0.62) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL650855 1.00 ALPI (0.62) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL244193 1.00 ALPI (0.62) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL7415433 1.00 ALPI (0.62) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL3841332 1.00 ALPI (0.62) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL2029167 1.00 ALPI (0.62) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL7698421 1.00 ALPI (0.62) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL7436847 1.00 ALPI (0.62) ALPIPKMPTGS1XIAPSLC7A5
Hydrochloric Acid SCHEMBL8951308 0.98 ALPI (0.60) ALPIPKMPTGS1XIAPSLC7A5
Hydrochloric Acid SCHEMBL1309497 0.98 ALPI (0.60) ALPIPKMPTGS1XIAPSLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606830-B2 Protected antibody-drug and aptamer-drug conjugates KOSAK KENNETH MICHAEL (US) 2026-04-21 — — US disclosed
CN-113004252-A Aryl imidazole derivative and application thereof 江苏先声药业有限公司 2021-06-22 — — CN disclosed
EP-1600457-B1 PEPTIDE DERIVATIVES HAVING BETA-SECRETASE INHIBITORY ACTIVITY KISO YOSHIAKI (JP) 2013-02-20 — — EP disclosed
US-7312188-B2 Peptide derivatives having β-secretase inhibitory activity KISO YOSHIAKI 2007-12-25 — — US disclosed
US-7307184-B2 Processes for preparing oxazolidinone derivatives of β-hydroxyethlamine compounds and for preparing β-hydroxyethlamine compounds KANEKA CORPORATION (JP) 2007-12-11 — — US disclosed
US-20070004637-A1 Peptide derivatives having beta-secretase inhibitory activity KISO YOSHIAKI 2007-01-04 — — US disclosed
US-20060135784-A1 PROCESS FOR PRODUCING 3-AMINO-2-HYDROXYPROPIONIC ACID DERIVATIVES KANEKA CORPORATION 2006-06-22 — — US disclosed
US-7057066-B2 Process for producing 3-amino-2-hydroxypropionic acid derivatives KANEKA CORPORATION (JP) 2006-06-06 — — US disclosed
EP-1600457-A1 PEPTIDE DERIVATIVES HAVING BETA-SECRETASE INHIBITORY ACTIVITY Kiso, Yoshiaki (JP) 2005-11-30 — — EP disclosed
US-6806384-B2 VIA TREATING N-CARBAMATE-PROTECTED BETA-AMINOEPOXIDE WITH ACID FORMING 5-HYDROXYMETHYL-2-OXAZOLIDINONE, THEN OXIDIZING IN 2,2,6,6-TETRAMETHYL-1-PIPERIDINYLOXY AND HYPOCHLORITE FORMING 4-BENZYL-2-OXO-5-OXAZOLIDINECARBOXYLIC ACID; CRYSTALLIZATION AJINOMOTO CO., INC. (JP) 2004-10-19 — — US disclosed
EP-1300391-A1 PROCESS FOR PRODUCING 3-AMINO-2-HYDROXYPROPIONIC ACID DERIVATIVES KANEKA CORPORATION (JP) 2003-04-09 — — EP disclosed
US-20020151722-A1 Production method of beta-amino-alpha-hydroxycarboxylic acid AJINOMOTO CO. INC (JP) 2002-10-17 — — US disclosed
US-6329502-B1 VIRICIDES AGAINST HUMAN IMMUNODEFICIENCY VIRUS; TREATMENT OF AIDS (ACQUIRED IMMUNE DEFICIENCY SYNDROME) JAPAN ENERGY CORPORATION (JP) 2001-12-11 — — US disclosed
US-6313094-B1 COMPOSITION FOR INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION JAPAN ENERGY CORPORATION (JP) 2001-11-06 — — US disclosed
US-6271238-B1 USEFUL IN TREATING AND PREVENTING DISEASES INVOLVING CHYMOTRYPSIN TYPE PROTEASES WHICH ARE RELATED TO ASTHMA, ALLERGY, INFLAMMATIONS, RHEUMATISM, HYPERTENSION, HEART FAILURE, MYOCARDIAL INFARCTION, AND CARDIAC HYPERTROPHY NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2001-08-07 — — US disclosed
EP-0936216-A1 NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1999-08-18 — — EP disclosed
US-5541290-A OLIGOPEPTIDE CONTAINING ALPHA-KETOAMIDE GROUP, TREATMENT OF ALZHEIMER*S DISEASE AND OTHER NEURODEGENERATIVE DISORDERS CORTEX PHARMACEUTICALS, INC. 1996-07-30 — — US disclosed
US-4668769-A Oxa- and azahomocyclostatine polypeptides PFIZER INC. 1987-05-26 — — US disclosed
EP-0211580-A2 Renin inhibiting polypeptides and intermediates therefor PFIZER INC. (US) 1987-02-25 — — EP disclosed
US-4599198-A Intermediates in polypeptide synthesis PFIZER INC. (US) 1986-07-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020151722-A1 Production method of beta-amino-alpha-hydroxycarboxylic acid HAO2, HAAO, DAO ALPI 401/4885PKM 3444/4885PTGS1 61/4885
US-12606830-B2 Protected antibody-drug and aptamer-drug conjugates PABPC1, PABPC4, ABCG2 ALPI 3844/4885PKM 2293/4885PTGS1 2629/4885
US-20060135784-A1 PROCESS FOR PRODUCING 3-AMINO-2-HYDROXYPROPIONIC ACID DERIVATIVES AASDHPPT, HPD, HAAO ALPI 2544/4885PKM 945/4885PTGS1 599/4885
US-20070004637-A1 Peptide derivatives having beta-secretase inhibitory activity BACE1, BACE2, APP ALPI 1496/4885PKM 4158/4885PTGS1 2317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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