SCHEMBL5493035

SCHEMBL5493035

C=CC[Si](Cl)(CC=C)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.33
TSHR P16473 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
CYP2C19 P33261 1/20 0.31
KDM4E B2RXH2 1/20 0.30
HPGD P15428 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
IDH1 O75874 1/20 0.30
NR1H2 P55055 1/20 0.30
NR1H3 Q13133 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14957505 0.88 NR1H2 (0.30) NR1H2NR1H3
SCHEMBL15302216 0.85
SCHEMBL73339 0.82 ALDH1A1 (0.33) ALDH1A1TSHRL3MBTL1CYP2C19KDM4E
SCHEMBL5491545 0.82 ALDH1A1 (0.33) ALDH1A1TSHRL3MBTL1CYP2C19KDM4E
SCHEMBL15302451 0.82 TSHR (0.30) TSHR
SCHEMBL9715855 0.78 NR1H2 (0.35) ALDH1A1TSHRL3MBTL1NR1H2NR1H3
SCHEMBL723613 0.78 ALDH1A1 (0.38) ALDH1A1TSHRL3MBTL1CYP2C19HPGD
SCHEMBL536223 0.76 ALDH1A1 (0.36) ALDH1A1TSHRL3MBTL1CYP2C19HPGD
SCHEMBL296966 0.76 ALDH1A1 (0.36) ALDH1A1TSHRL3MBTL1CYP2C19HPGD
SCHEMBL7118374 0.74 ALDH1A1 (0.35) ALDH1A1TSHRL3MBTL1CYP2C19IDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0361827-A1 Pyrazole compounds, method for production thereof, use thereof and intermediates for production thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1990-04-04 EP claimed
CN-117891131-A Hydrophobic low-temperature cured resin composition and preparation method and application thereof 阜阳欣奕华材料科技有限公司 2024-04-16 CN disclosed
US-8791221-B2 Addition-curable metallosiloxane compound DAICEL CORPORATION (JP) 2014-07-29 US disclosed
EP-2650319-A1 ADDITION-CURABLE METALLOSILOXANE COMPOUND Daicel Corporation (JP) 2013-10-16 EP disclosed
US-20130267653-A1 ADDITION-CURABLE METALLOSILOXANE COMPOUND DAICEL CORPORATION (JP) 2013-10-10 US disclosed
CN-103249762-A Addition-curable metallosiloxane compound DAICEL CORP 2013-08-14 CN disclosed
CN-100427490-C Process for preparing allyl chlorosilane HANGZHOU TEACHERS COLLEGE (CN) 2008-10-22 CN disclosed
US-7232799-B2 Streptogramin derivatives and compositions thereof AVENTIS PHARMA SA (FR) 2007-06-19 US disclosed
CN-1880321-A Process for preparing allyl chlorosilane HANGZHOU TEACHERS COLLEGE (CN) 2006-12-20 CN disclosed
US-20050267181-A1 Streptogramin derivatives and compositions thereof AVENTIS PHARMA S.A. (FR) 2005-12-01 US disclosed
US-6962901-B2 Streptogramin derivatives, their preparation and compositions which contain them AVENTIS PHARMA S.A. (FR) 2005-11-08 US disclosed
US-20030207928-A1 Streptogramin derivatives, their preparation and compositions which contain them AVENTIS PHARMA S.A. 2003-11-06 US disclosed
US-6596717-B2 As antibiotic agent AVENTIS PHARMA S.A. (FR) 2003-07-22 US disclosed
US-20020143041-A1 Streptogramin derivatives, their preparation and compositions which contain them AVENTIS PHARMA S.A. (FR) 2002-10-03 US disclosed
US-6288066-B1 ANTIDIABETIC AGENTS; OXIDATION, HYDROLYSIS AVENTIS PHARMA S.A. (FR) 2001-09-11 US disclosed
EP-0361827-B1 PYRAZOLE COMPOUNDS, METHOD FOR PRODUCTION THEREOF, USE THEREOF AND INTERMEDIATES FOR PRODUCTION THEREOF SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1992-12-16 EP disclosed
US-5028714-A Chemical intermediate for fungicide, miticide, insecticide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-07-02 US disclosed
US-4980345-A INSECTICIDES, ACARICIDES, FUNGICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1990-12-25 US disclosed
EP-0361827-A1 Pyrazole compounds, method for production thereof, use thereof and intermediates for production thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1990-04-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030207928-A1 Streptogramin derivatives, their preparation and compositions which contain them MRPL21, SPG11, STT3B ALDH1A1 4753/4885TSHR 3551/4885L3MBTL1 4860/4885
US-20020143041-A1 Streptogramin derivatives, their preparation and compositions which contain them MRPL21, SPG11, STT3B ALDH1A1 4753/4885TSHR 3551/4885L3MBTL1 4860/4885
US-20050267181-A1 Streptogramin derivatives and compositions thereof SPG11, SRI, BSG ALDH1A1 4648/4885TSHR 3126/4885L3MBTL1 4837/4885
US-20130267653-A1 ADDITION-CURABLE METALLOSILOXANE COMPOUND B2M, MSI2, MNS1 ALDH1A1 2073/4885TSHR 4702/4885L3MBTL1 670/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.