SCHEMBL228960

SCHEMBL228960

CON1C(=O)CCC(=O)[C@]1(C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)C(Cl)C(=O)C(Cl)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@]1(C)C(=O)CCC(=O)N1OC)C(C)C)C(C)C

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ELANE P08246 16/20 0.38
CMA1 P23946 1/20 0.33
XIAP P98170 2/20 0.33
MLX Q9UH92 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL230923 0.93 ELANE (0.33) ELANECMA1
SCHEMBL2289363 0.90 ELANE (0.42) ELANECMA1XIAPMLX
SCHEMBL5487413 0.89 ELANE (0.38) ELANECMA1XIAPMLX
SCHEMBL3276266 0.87 ELANE (0.42) ELANECMA1XIAPMLX
SCHEMBL8662040 0.87 ELANE (0.40) ELANECMA1XIAPMLX
SCHEMBL535732 0.83 ACE (0.40)
SCHEMBL387694 0.81 TACR1 (0.40) ELANECMA1XIAPMLX
SCHEMBL5494650 0.81 ELANE (0.40) ELANECMA1XIAPMLX
SCHEMBL8661389 0.78 ELANE (0.36) ELANECMA1
SCHEMBL847832 0.78 CMA1 (0.49) CMA1XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 223 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7964350-B1 Sample preparation for in situ nucleic acid analysis APPLIED BIOSYSTEMS, LLC (US) 2011-06-21 US claimed
CN-101434945-A Nematophagous fungi infectious extracellular serine proteinase crystal morphology UNIV YUNNAN (CN) 2009-05-20 CN claimed
US-5683867-A NUCLEIC ACID LIGANDS, BLENDING, PARTITIONING AND AMPLIFICATION NEXSTAR PHARMACEUTICALS, INC. (US) 1997-11-04 US claimed
US-20240226610-A1 TOPICAL SKIN FORMULATIONS MARY KAY INC. 2024-07-11 US disclosed
US-20240226216-A1 METHODS AND COMPOSITIONS FOR TREATING STRIAE DISTENSAE MARY KAY INC. 2024-07-11 US disclosed
US-20240216262-A1 COSMETIC COMPOSITIONS AND METHODS OF USING SAME MARY KAY INC. (US) 2024-07-04 US disclosed
US-12005135-B2 Barrier guard technology MARY KAY INC. (US) 2024-06-11 US disclosed
US-20240165014-A1 COSMETIC COMPOSITIONS MARY KAY INC. 2024-05-23 US disclosed
EP-3851093-B1 TOPICAL COMPOSITIONS MARY KAY INC (US) 2024-05-22 EP disclosed
US-20240157177-A1 COSMETIC COMPOSITIONS AND USES THEREOF ALLUSTRA TECHNOLOGIES LLC 2024-05-16 US disclosed
EP-4363062-A1 TOPICAL COMPOSITION AGAINST FINE LINES AND WRINKLES Mary Kay, Inc. (US) 2024-05-08 EP disclosed
US-20030077646-A1 Systematic evolution of ligands by exponential enrichment: blended SELEX GILEAD SCIENCES, INC. (US) 2003-04-24 US disclosed
US-6465189-B1 PARTITIONING AND REPLICATING INCREASED AFFINITY BLENDED NUCLEIC ACIDS; DEVELOPMENT OF ELASTASE INHIBITORS; MEDICAL DIAGNOSIS OF RESPIRATORY SYSTEM, GENETIC, AND RHEUMATIC DISORDERS GILEAD SCIENCES, INC. 2002-10-15 US disclosed
US-6465189-B1 PARTITIONING AND REPLICATING INCREASED AFFINITY BLENDED NUCLEIC ACIDS; DEVELOPMENT OF ELASTASE INHIBITORS; MEDICAL DIAGNOSIS OF RESPIRATORY SYSTEM, GENETIC, AND RHEUMATIC DISORDERS GILEAD SCIENCES, INC. 2002-10-15 US disclosed
US-6083696-A DETECTION OF BLENDED NUCLEIC ACID LIGANDS OF A TARGET COMPOUND; INCUBATION OF BLENDED NUCLEIC ACID MIXTURE WITH THE TARGET, SEPARATING BLENDED NUCLEIC ACIDS WITH INCREASED RECEPTIVITY, AMPLIFYING BLENDED NUCLEIC ACIDS NEXSTAR PHARMACEUTICALS, INC. (US) 2000-07-04 US disclosed
US-5734034-A Nucleic acid ligand inhibitors of human neutrophil elastase NEXSTAR PHARMACEUTICALS, INC. (US) 1998-03-31 US disclosed
US-5683867-A NUCLEIC ACID LIGANDS, BLENDING, PARTITIONING AND AMPLIFICATION NEXSTAR PHARMACEUTICALS, INC. (US) 1997-11-04 US disclosed
EP-0724647-A1 NUCLEIC ACID LIGANDS AND IMPROVED METHODS FOR PRODUCING THE SAME NeXstar Pharmaceuticals, Inc. (US) 1996-08-07 EP disclosed
US-5472841-A Partitioning the increased affinity nucleic acids from remainder mixture, amplifying the nucleic acids to yield high affinity nucleic acid NEXSTAR PHARMACEUTICALS, INC. (US) 1995-12-05 US disclosed
WO-1995007364-A1 NUCLEIC ACID LIGANDS AND IMPROVED METHODS FOR PRODUCING THE SAME NEXSTAR PHARMACEUTICALS, INC. (US) 1995-03-16 WO disclosed