Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 2/20 | 0.33 |
| ▸ | MLX | Q9UH92 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2289363 | 0.88 | ELANE (0.42) | ELANECMA1XIAPMLX | |
| SCHEMBL5487413 | 0.87 | ELANE (0.38) | ELANECMA1XIAPMLX | |
| SCHEMBL228960 | 0.87 | ELANE (0.38) | ELANECMA1XIAPMLX | |
| SCHEMBL8662040 | 0.85 | ELANE (0.40) | ELANECMA1XIAPMLX | |
| SCHEMBL230923 | 0.83 | ELANE (0.33) | ELANECMA1 | |
| SCHEMBL535732 | 0.82 | ACE (0.40) | — | |
| SCHEMBL387694 | 0.81 | TACR1 (0.40) | ELANECMA1XIAPMLX | |
| SCHEMBL5494650 | 0.79 | ELANE (0.40) | ELANECMA1XIAPMLX | |
| SCHEMBL1675958 | 0.79 | MEN1 (0.39) | ELANE | |
| SCHEMBL847832 | 0.78 | CMA1 (0.49) | CMA1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7695948-B2 | Antibodies that bind TNF-α converting enzyme | IMMUNEX CORPORATION (US) | 2010-04-13 | — | — | US | disclosed |
| US-20080160571-A1 | Antibodies that bind TNF-alpha converting enzyme | IMMUNEX CORPORATION (US) | 2008-07-03 | — | — | US | disclosed |
| US-7199224-B2 | Antibodies that bind TNF-α converting enzyme | IMMUNEX CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| EP-0830130-B9 | TNF-ALPHA CONVERTING ENZYME | IMMUNEX CORP (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-0830130-B1 | TNF-ALPHA CONVERTING ENZYME | IMMUNEX CORP (US) | 2004-08-25 | — | — | EP | disclosed |
| US-20030175816-A1 | Antibodies that bind TNF-alpha converting enzyme | IMMUNEX CORPORATION | 2003-09-18 | — | — | US | disclosed |
| US-6555354-B2 | Enzymatic polypeptide for use in the treatment of inflammation, reperfusion injury, viral diseases, allergies, infections, pain, autoimmune,cardiovascular, nervous system, kidney, urogenital, sexual, kidney disorders | IMMUNEX CORPORATION | 2003-04-29 | — | — | US | disclosed |
| US-6406877-B2 | PURIFIED AND ISOLATED TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME, THE NUCLEIC ACIDS THAT ENCODE IT, AND PROCESSES FOR ITS RECOMBINATION | IMMUNEX CORPORATION | 2002-06-18 | — | — | US | disclosed |
| US-6406901-B1 | TNF-a converting enzyme | IMMUNEX CORPORATION | 2002-06-18 | — | — | US | disclosed |
| US-20010024816-A1 | TNF-alpha converting enzyme | BLACK ROY A (US) | 2001-09-27 | — | — | US | disclosed |
| US-6013466-A | TNF-α converting enzyme | IMMUNEX CORPORATION (US) | 2000-01-11 | — | — | US | disclosed |
| US-5830742-A | TNF-α converting enzyme | IMMUNEX CORPORATION (US) | 1998-11-03 | — | — | US | disclosed |