Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13811014 | 0.84 | GAA (0.50) | MEN1KMT2AGAALMNAMAPT | |
| SCHEMBL9396485 | 0.83 | MAPT (0.52) | MEN1KMT2ALMNAMAPTTHRB | |
| SCHEMBL1291798 | 0.81 | LMNA (0.50) | PKMMEN1KMT2AGAALMNA | |
| SCHEMBL4347040 | 0.79 | CYP1A2 (0.52) | MEN1KMT2ALMNAMAPTCYP1A2 | |
| Hydrochloric Acid SCHEMBL5491741 | 0.78 | HTR2A (0.44) | MEN1KMT2ALMNAMAPTTDP1 | |
| SCHEMBL28664013 | 0.76 | MAPT (0.51) | MEN1KMT2ALMNAMAPTTDP1 | |
| SCHEMBL11447660 | 0.76 | CHEK1 (0.56) | MEN1KMT2ALMNAMAPTNPC1 | |
| SCHEMBL2848376 | 0.76 | ALDH1A1 (0.63) | MEN1KMT2ALMNAMAPTRAB9A | |
| SCHEMBL11017748 | 0.75 | TDP1 (0.67) | PKMMEN1KMT2AGAALMNA | |
| SCHEMBL8513944 | 0.75 | MAPT (0.55) | PKMMEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907363-B1 | Medicament comprising (-)-8-[(4-amino-1-méthylbutyl)amino]-5-(3,4-dichlorophénoxy)-6-méthoxy-4-méthylquinoline for the treatment of parasitic and opportunistic infections | UNIV MISSISSIPPI (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-0907363-A4 | 8-AMINOQUINOLINES | UNIV MISSISSIPPI (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6376511-B2 | ENANTIOMERS OF 8-AMINOQUINOLINE; ANTIPARASITIC COMPOUNDS FOR TREATMENT OR PREVENTION OF PNEUMOCYSTIS CARINII PNEUMONIA, TOXOPLASMOSIS, MALARIA, LEISHMANIASIS, OR TRYPSONOSOMIA | THE UNIVERSITY OF MISSISSIPPI | 2002-04-23 | — | — | US | disclosed |
| US-20010007031-A1 | 8-AMINOQUINOLINES | UNIVERSITY OF MIAMI, THE | 2001-07-05 | — | — | US | disclosed |
| EP-0907363-A1 | 8-AMINOQUINOLINES | THE UNIVERSITY OF MISSISSIPPI (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997036590-A1 | 8-AMINOQUINOLINES | THE UNIVERSITY OF MISSISSIPPI (US) | 1997-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010007031-A1 | 8-AMINOQUINOLINES | CYP2C8, COQ8A, TUBA8 | PKM 1874/4885MEN1 3524/4885KMT2A 207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.