Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24804617 | 0.86 | NPC1 (0.69) | ALDH1A1NPC1RAB9APOLBMAPT | |
| SCHEMBL28441954 | 0.84 | NPC1 (0.69) | ALDH1A1NPC1RAB9APOLBMAPT | |
| SCHEMBL28440101 | 0.84 | ALDH1A1 (0.73) | ALDH1A1NPC1RAB9APOLBMAPT | |
| SCHEMBL6734167 | 0.83 | POLB (0.62) | ALDH1A1NPC1RAB9APOLBMAPT | |
| SCHEMBL10816709 | 0.81 | LMNA (0.72) | ALDH1A1NPC1RAB9APOLBMAPT | |
| SCHEMBL28442458 | 0.81 | NPC1 (0.72) | ALDH1A1NPC1RAB9APOLBMAPT | |
| SCHEMBL5783680 | 0.81 | ALDH1A1 (0.57) | ALDH1A1NPC1RAB9APOLBMAPT | |
| SCHEMBL24804696 | 0.80 | LMNA (0.72) | ALDH1A1NPC1RAB9APOLBMAPT | |
| SCHEMBL31276466 | 0.80 | NPC1 (0.58) | ALDH1A1NPC1RAB9APOLBMAPT | |
| SCHEMBL9424254 | 0.80 | LMNA (0.74) | ALDH1A1NPC1RAB9APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111747946-A | 5-benzofuran-1, 3, 4-thiadiazole-2-substituted amide compound and preparation method and application thereof | 河北大学 | 2020-10-09 | — | — | CN | claimed |
| US-20220411419-A1 | SMALL MOLECULE MODULATORS OF MHC-I | RETROVIROX, INC. | 2022-12-29 | — | — | US | disclosed |
| CN-111747946-B | 5-benzofuran-1, 3, 4-thiadiazole-2-substituted amide compound and preparation method and application thereof | 河北大学 | 2021-12-31 | — | — | CN | disclosed |
| CN-111747946-A | 5-benzofuran-1, 3, 4-thiadiazole-2-substituted amide compound and preparation method and application thereof | 河北大学 | 2020-10-09 | — | — | CN | disclosed |
| US-7157430-B2 | (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases | IDUN PHARMACEUTICALS, INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-20040259804-A1 | (Substituted)Acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases | IDUN PHARMACEUTICALS, INC. | 2004-12-23 | — | — | US | disclosed |
| US-20020091089-A1 | (Substituted)acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases | KARANEWSKY DONALD S (US) | 2002-07-11 | — | — | US | disclosed |
| EP-1123272-A1 | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | Idun Pharmaceuticals, Inc. (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6242422-B1 | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases | IDUN PHARMACUETICALS, INC. | 2001-06-05 | — | — | US | disclosed |
| WO-2000023421-A1 | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES | IDUN PHARMACEUTICALS, INC. (US) | 2000-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220411419-A1 | SMALL MOLECULE MODULATORS OF MHC-I | CD74, HLA-DRB1, MICA | ALDH1A1 233/4885NPC1 1126/4885RAB9A 1829/4885 |
| US-20020091089-A1 | (Substituted)acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases | DPP3, IAPP, CASP3 | ALDH1A1 2658/4885NPC1 1417/4885RAB9A 3967/4885 |
| US-20040259804-A1 | (Substituted)Acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases | DPP3, IAPP, CASP3 | ALDH1A1 2658/4885NPC1 1417/4885RAB9A 3967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.