Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.44 |
| ▸ | MAOB | P27338 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498198 | 0.85 | MAOA (0.43) | MAOAMAOBPOLBALDH1A1GAA | |
| SCHEMBL6442964 | 0.78 | MAOA (0.50) | MAOAMAOBKDM4ENSD2MAPT | |
| SCHEMBL5493085 | 0.78 | MAOA (0.72) | MAOAMAOBKDM4ENSD2MAPT | |
| SCHEMBL11545426 | 0.71 | KDM4E (0.59) | MAOAMAOBKDM4ENSD2MAPT | |
| SCHEMBL14534512 | 0.71 | MAOA (0.60) | MAOAMAOBKDM4ENSD2MAPT | |
| SCHEMBL6442958 | 0.70 | MAOA (0.44) | MAOAMAOBKDM4ENSD2MAPT | |
| Hydrochloric Acid SCHEMBL11065248 | 0.68 | MAOA (0.62) | MAOAMAOBKDM4ENSD2MAPT | |
| SCHEMBL10949994 | 0.67 | HSP90AA1 (0.56) | MAOAMAOBKDM4ENSD2MAPT | |
| SCHEMBL11072989 | 0.67 | MAOA (0.71) | MAOAMAOBKDM4ENSD2MAPT | |
| SCHEMBL10944231 | 0.66 | HSP90AA1 (0.58) | MAOAMAOBKDM4ENSD2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907363-B1 | Medicament comprising (-)-8-[(4-amino-1-méthylbutyl)amino]-5-(3,4-dichlorophénoxy)-6-méthoxy-4-méthylquinoline for the treatment of parasitic and opportunistic infections | UNIV MISSISSIPPI (US) | 2007-05-23 | — | — | EP | disclosed |
| US-6376511-B2 | ENANTIOMERS OF 8-AMINOQUINOLINE; ANTIPARASITIC COMPOUNDS FOR TREATMENT OR PREVENTION OF PNEUMOCYSTIS CARINII PNEUMONIA, TOXOPLASMOSIS, MALARIA, LEISHMANIASIS, OR TRYPSONOSOMIA | THE UNIVERSITY OF MISSISSIPPI | 2002-04-23 | — | — | US | disclosed |
| US-20010007031-A1 | 8-AMINOQUINOLINES | UNIVERSITY OF MIAMI, THE | 2001-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010007031-A1 | 8-AMINOQUINOLINES | CYP2C8, COQ8A, TUBA8 | MAOA 963/4885MAOB 1272/4885KDM4E 632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.