Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786716 | 0.89 | AKR1C3 (0.57) | MEN1KMT2AAKR1C3RECQLMTNR1A | |
| SCHEMBL388143 | 0.89 | AKR1C3 (0.57) | MEN1KMT2AAKR1C3RECQLMTNR1A | |
| SCHEMBL388142 | 0.89 | AKR1C3 (0.57) | MEN1KMT2AAKR1C3RECQLMTNR1A | |
| SCHEMBL387760 | 0.87 | AKR1C3 (0.55) | MEN1KMT2AAKR1C3RECQLMTNR1A | |
| Methyl Alcohol SCHEMBL8740650 | 0.87 | AKR1C3 (0.55) | MEN1KMT2AAKR1C3RECQLMTNR1A | |
| SCHEMBL847144 | 0.81 | KMT2A (0.49) | MEN1KMT2ANPC1L3MBTL1ALDH1A1 | |
| SCHEMBL15085946 | 0.80 | TP53 (0.56) | MEN1KMT2AAKR1C3RECQLALDH1A1 | |
| SCHEMBL14135332 | 0.79 | AKR1C3 (0.48) | MEN1KMT2AAKR1C3RECQLMTNR1A | |
| SCHEMBL12561790 | 0.79 | RECQL (0.53) | MEN1KMT2AAKR1C3RECQLMTNR1A | |
| Methyl Alcohol SCHEMBL8740641 | 0.78 | AKR1C3 (0.47) | MEN1KMT2AAKR1C3RECQLMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567535-B1 | BIDENTATE C,P CHIRAL PHOSPHINE LIGANDS | HOFFMANN LA ROCHE (CH) | 2007-01-17 | — | — | EP | disclosed |
| US-6984744-B2 | Phosphine ligands | HOFFMAN-LA ROCHE INC. (US) | 2006-01-10 | — | — | US | disclosed |
| EP-1567535-A1 | BIDENTATE C,P CHIRAL PHOSPHINE LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050669-A1 | BIDENTATE C,P CHIRAL PHOSPHINE LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-17 | — | — | WO | disclosed |
| US-20040110975-A1 | 2-(2-phosphinoethyl)phospholanes and transition metal complexes with such ligands in asymmetric hydrogenation reactions; phospholone intermediates | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110975-A1 | 2-(2-phosphinoethyl)phospholanes and transition metal complexes with such ligands in asymmetric hydrogenation reactions; phospholone intermediates | CCRL2, LUC7L2, CDKL1 | MEN1 2235/4885KMT2A 925/4885AKR1C3 748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.