Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500263 | 0.92 | KCNH2 (0.41) | SIGMAR1SLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL5495685 | 0.87 | DPP4 (0.39) | RENKCNH2DRD2CYP2D6 | |
| SCHEMBL5499282 | 0.87 | SIGMAR1 (0.51) | SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL17186727 | 0.85 | SLC6A4 (0.40) | SLC6A2SLC6A4SLC6A3DRD2TRPA1 | |
| SCHEMBL5499921 | 0.82 | IDO1 (0.43) | SIGMAR1SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL5502520 | 0.81 | KCNH2 (0.41) | SIGMAR1SLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL5237164 | 0.79 | OPRM1 (0.39) | SLC6A2SLC6A4SLC6A3KCNH2DRD2 | |
| SCHEMBL5500050 | 0.78 | KCNH2 (0.43) | RENKCNH2 | |
| SCHEMBL5499307 | 0.78 | SIGMAR1 (0.49) | SIGMAR1SLC6A2SLC6A4KCNH2 | |
| Hydrochloric Acid SCHEMBL7983042 | 0.77 | KCNH2 (0.42) | RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765779-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005121092-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |