Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | PNMT | P11086 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499307 | 0.91 | SIGMAR1 (0.49) | SIGMAR1SLC6A2SLC6A4PRMT5WDR77 | |
| SCHEMBL5500258 | 0.87 | SIGMAR1 (0.38) | SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL15537060 | 0.84 | SLC6A2 (0.49) | SIGMAR1SLC6A2SLC6A4PRMT5WDR77 | |
| SCHEMBL5499921 | 0.83 | IDO1 (0.43) | SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL5500263 | 0.79 | KCNH2 (0.41) | SIGMAR1SLC6A2SLC6A4IGF1RALOX15 | |
| SCHEMBL5502520 | 0.79 | KCNH2 (0.41) | SIGMAR1SLC6A2SLC6A4IGF1RALOX15 | |
| SCHEMBL5495685 | 0.78 | DPP4 (0.39) | — | |
| SCHEMBL5237164 | 0.76 | OPRM1 (0.39) | SLC6A2SLC6A4TAAR1 | |
| SCHEMBL5498980 | 0.76 | GPR84 (0.46) | SLC6A2SLC6A4 | |
| SCHEMBL5672427 | 0.75 | OPRM1 (0.55) | SIGMAR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765779-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005121092-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |