Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | ACAT2 | Q9BWD1 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502511 | 0.91 | TAAR1 (0.45) | TAAR1SLC6A2SLC6A4PNMTKCNH2 | |
| SCHEMBL5499318 | 0.86 | KCNH2 (0.33) | TAAR1SLC6A2SLC6A4KCNH2REN | |
| SCHEMBL5493818 | 0.86 | FFAR4 (0.41) | SLC6A2SLC6A4KCNH2RENDRD2 | |
| SCHEMBL5500092 | 0.83 | FFAR4 (0.43) | SLC6A2SLC6A4KCNH2RENCYP3A4 | |
| SCHEMBL5495138 | 0.80 | KCNH2 (0.37) | SLC6A2SLC6A4KCNH2RENALDH1A1 | |
| SCHEMBL5495293 | 0.80 | P2RX7 (0.38) | SLC6A2SLC6A4KCNH2SLC6A3CYP2D6 | |
| SCHEMBL5501439 | 0.77 | FFAR4 (0.40) | SLC6A2SLC6A4KCNH2RENDRD2 | |
| SCHEMBL5498352 | 0.77 | DRD2 (0.34) | TAAR1SLC6A2SLC6A4KCNH2REN | |
| SCHEMBL4390004 | 0.77 | FFAR4 (0.39) | SLC6A2SLC6A4KCNH2RENDRD2 | |
| SCHEMBL5499300 | 0.74 | SLC6A2 (0.45) | SLC6A2SLC6A4KCNH2RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765779-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-03-28 | — | — | EP | claimed |
| WO-2005121092-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |
| EP-1765779-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005121092-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |