Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Clonazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 5/20 | 0.74 |
| ▸ | GABRA5 known ✓ | P31644 | 5/20 | 0.74 |
| ▸ | GABRA3 known ✓ | P34903 | 5/20 | 0.74 |
| ▸ | GABRA2 known ✓ | P47869 | 5/20 | 0.74 |
| ▸ | GABRB2 known ✓ | P47870 | 4/20 | 0.74 |
| ▸ | GABRG2 known ✓ | P18507 | 4/20 | 0.74 |
| ▸ | GABRB3 known ✓ | P28472 | 4/20 | 0.74 |
| ▸ | GABRP known ✓ | O00591 | 3/20 | 0.74 |
| ▸ | GABRD known ✓ | O14764 | 3/20 | 0.74 |
| ▸ | GABRB1 known ✓ | P18505 | 3/20 | 0.74 |
| ▸ | GABRA4 known ✓ | P48169 | 3/20 | 0.74 |
| ▸ | GABRE known ✓ | P78334 | 3/20 | 0.74 |
| ▸ | GABRA6 known ✓ | Q16445 | 3/20 | 0.74 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 3/20 | 0.74 |
| ▸ | GABRG3 known ✓ | Q99928 | 3/20 | 0.74 |
| ▸ | GABRQ known ✓ | Q9UN88 | 3/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | PGR | P06401 | 1/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrazepam SCHEMBL1956552 | 0.89 | LMNA (0.70) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL31365170 | 0.88 | LMNA (0.71) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL20771795 | 0.86 | GABRA1 (0.96) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL38899 | 0.86 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL13747803 | 0.86 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL5501860 | 0.86 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL29369721 | 0.86 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL29743048 | 0.86 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL29361251 | 0.86 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Clonazepam SCHEMBL13746712 | 0.86 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150190404-A1 | TREATING SEIZURES USING ICE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2015-07-09 | — | — | US | disclosed |
| EP-1750689-A1 | TREATING SEIZURES USING ICE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2007-02-14 | — | — | EP | disclosed |
| US-20060128696-A1 | Treating seizures using ice inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2006-06-15 | — | — | US | disclosed |
| WO-2005115362-A1 | TREATING SEIZURES USING ICE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128696-A1 | Treating seizures using ice inhibitors | PSEN2, MAPT, PSEN1 | GABRA1 473/4885GABRA5 325/4885GABRA3 392/4885 |
| US-20150190404-A1 | TREATING SEIZURES USING ICE INHIBITORS | PSEN2, MAPT, PSEN1 | GABRA1 473/4885GABRA5 325/4885GABRA3 392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.