Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507178 | 0.84 | P2RX7 (0.38) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL3881879 | 0.76 | LMNA (0.38) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL5499906 | 0.73 | LMNA (0.44) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL5504616 | 0.73 | LMNA (0.44) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL5503369 | 0.70 | LMNA (0.43) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL2994152 | 0.68 | SIGMAR1 (0.56) | ALDH1A1KMT2AMEN1OPRL1MAPT | |
| SCHEMBL4503607 | 0.67 | GRIN1 (0.46) | ALDH1A1KMT2AMEN1OPRL1MAPT | |
| SCHEMBL4502450 | 0.66 | OPRM1 (0.39) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5501727 | 0.66 | P2RX7 (0.40) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL5501783 | 0.65 | LMNA (0.43) | ALDH1A1KMT2AMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |