Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3772831 | 0.82 | P2RX7 (0.47) | CYP2A6NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4032281 | 0.82 | NOTUM (0.63) | NPC1RAB9ASMN1; SMN2MAPK14NOTUM | |
| SCHEMBL30708901 | 0.82 | NOTUM (0.63) | NPC1RAB9ASMN1; SMN2MAPK14NOTUM | |
| SCHEMBL5005152 | 0.80 | NPC1 (0.45) | CYP2A6NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL23628571 | 0.79 | CYP2A6 (1.00) | CYP2A6NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL12853983 | 0.79 | NOTUM (0.60) | NPC1RAB9ASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL1947212 | 0.79 | NOTUM (0.60) | NPC1RAB9ASMN1; SMN2CYP1A2CYP3A4 | |
| Benzene SCHEMBL28342327 | 0.79 | CYP2A6 (1.00) | CYP2A6NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL29355088 | 0.79 | CYP2A6 (1.00) | CYP2A6NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL170230 | 0.79 | CYP2A6 (1.00) | CYP2A6NPC1RAB9ASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4405792-A | Substituted pyridines and their preparation | ETHYL CORPORATION (US) | 1983-09-20 | — | — | US | claimed |
| US-8110642-B2 | Synthesis of vinylphenylpyridine and living anionic polymerization | GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-02-07 | — | — | US | disclosed |
| US-20110077395-A1 | INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I | BRISTOL-MYERS SQUIBB COMPANY | 2011-03-31 | — | — | US | disclosed |
| US-20110077395-A1 | INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I | BRISTOL-MYERS SQUIBB COMPANY | 2011-03-31 | — | — | US | disclosed |
| US-7622486-B2 | Pyridine compounds, process for their preparation and compositions containing them | REDDY US THERAPEUTICS, INC. (US) | 2009-11-24 | — | — | US | disclosed |
| EP-1805142-A4 | NOVEL PYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | REDDY US THERAPEUTICS INC (US) | 2009-06-10 | — | — | EP | disclosed |
| US-20090105416-A1 | Synthesis of Vinylphenylpyridine and Living Anionic Polymerization | GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-04-23 | — | — | US | disclosed |
| WO-2007129810-A1 | SYNTHESIS OF VINYLPHENYLPYRIDINE AND LIVING ANIONIC POLYMERIZATION | GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2007-11-15 | — | — | WO | disclosed |
| EP-1805142-A2 | NOVEL PYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | Reddy US Therapeutics, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| US-20060084644-A1 | Novel pyridine compounds, process for their preparation and compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2006-04-20 | — | — | US | disclosed |
| WO-2006034474-A2 | NOVEL PYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | REDDY US THERAPEUTICS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |
| US-4533735-A | Process for preparing antibacterial compounds | ETHYL CORPORATION (US) | 1985-08-06 | — | — | US | disclosed |
| US-4490535-A | 4-(3- and 4-Chlorocyclohex-3-enyl)pyridine intermediates | ETHYL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| US-4405792-A | Substituted pyridines and their preparation | ETHYL CORPORATION (US) | 1983-09-20 | — | — | US | disclosed |
| US-4405792-A | Substituted pyridines and their preparation | ETHYL CORPORATION (US) | 1983-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077395-A1 | INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I | HSD11B1, HSD3B1, HSD17B1 | CYP2A6 249/4885NPC1 303/4885RAB9A 758/4885 |
| US-20060084644-A1 | Novel pyridine compounds, process for their preparation and compositions containing them | LDLR, LRP6, PLPBP | CYP2A6 3558/4885NPC1 1840/4885RAB9A 3129/4885 |
| US-20090105416-A1 | Synthesis of Vinylphenylpyridine and Living Anionic Polymerization | PBRM1, MVD, PCBP1 | CYP2A6 1144/4885NPC1 4810/4885RAB9A 4209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.