Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 7/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 7/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 7/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5116354 | 0.99 | ATAD2 (0.43) | ATAD2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL5107121 | 0.86 | ATAD2 (0.48) | ATAD2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL5510757 | 0.84 | BMPR1B (0.48) | ATAD2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL4201949 | 0.82 | BMPR1B (0.49) | ATAD2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL5122585 | 0.78 | NOTUM (0.45) | KMT2A | |
| SCHEMBL5115938 | 0.77 | GAA (0.48) | LMNACASP1CASP7MAPTMEN1 | |
| SCHEMBL5121407 | 0.74 | F10 (0.45) | LMNAPTGS1 | |
| SCHEMBL5120654 | 0.74 | F10 (0.45) | LMNAPTGS1 | |
| SCHEMBL5121418 | 0.74 | F10 (0.45) | LMNAPTGS1 | |
| SCHEMBL5504881 | 0.73 | MAOA (0.47) | LMNAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781643-A1 | OXINDOLE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS | Pharmacia & Upjohn Company LLC (US) | 2007-05-09 | — | — | EP | disclosed |
| EP-1781642-A1 | OXAZOLIDINONES CONTAINING OXINDOLES AS ANTIBACTERIAL AGENTS | Pharmacia & Upjohn Company LLC (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006016220-A1 | OXINDOLE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-02-16 | — | — | WO | disclosed |
| WO-2006016221-A1 | OXAZOLIDINONES CONTAINING OXINDOLES AS ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-02-16 | — | — | WO | disclosed |