Water

Water

SCHEMBL5501375

NCCCC[C@H](N)C(=O)OC(=O)CCC(=O)OC(=O)[C@@H](N)CCCCN.O

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
DPP4 known ✓ P27487 4/20 0.37
GSR P00390 1/20 0.52
GNAI3 P08754 1/20 0.38
GNAO1 P09471 1/20 0.38
GNAI1 P63096 1/20 0.38
DPP7 Q9UHL4 10/20 0.37
DPP8 Q6V1X1 5/20 0.37
DPP9 Q86TI2 4/20 0.37
RNPEP Q9H4A4 1/20 0.37
CYP1A2 P05177 1/20 0.37
CPB2 Q96IY4 2/20 0.37
FOLH1 Q04609 1/20 0.37
CYP2D6 P10635 1/20 0.34
NFKB1 P19838 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1191631 0.98 GSR (0.53) GSRGNAI3GNAO1GNAI1DPP7
SCHEMBL5010331 0.98 GSR (0.53) GSRGNAI3GNAO1GNAI1DPP7
SCHEMBL8836488 0.96 GSR (0.52) GSRGNAI3GNAO1GNAI1DPP7
SCHEMBL8836895 0.96 GSR (0.52) GSRGNAI3GNAO1GNAI1DPP7
Water SCHEMBL6560978 0.93 GSR (0.48) GSRGNAI3GNAO1GNAI1DPP7
Water SCHEMBL6034325 0.93 GSR (0.48) GSRGNAI3GNAO1GNAI1DPP7
SCHEMBL1065054 0.93 GSR (0.52) GSRGNAI3GNAO1GNAI1DPP7
SCHEMBL8759024 0.93 GSR (0.52) GSRGNAI3GNAO1GNAI1DPP7
SCHEMBL8950857 0.93 GSR (0.52) GSRGNAI3GNAO1GNAI1DPP7
SCHEMBL237121 0.93 GSR (0.52) GSRGNAI3GNAO1GNAI1DPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1163853-B1 METHOD OF STRENGTHENIG THE TASTE OF SODIUM CHLORIDE, AGENT FOR STRENGTHENING THE TASTE OF SODIUM CHLORIDE, SODIUM CHLORIDE-TASTE SEASONING AND FOOD HAVING STRENGTHENED TASTE OF SODIUM CHLORIDE KYOWA HAKKO FOOD SPECIALTIES C (JP) 2007-02-21 EP disclosed
US-6974597-B2 Method of enhancing salty taste, salty taste enhancer, salty taste seasoning agent and salty taste-enhanced foods KYOWA HAKKO KOGYO CO., LTD. (JP) 2005-12-13 US disclosed
US-20030091721-A1 Method of enhancing salty taste, salty taste enhancer, salty taste seasoning agent and salty taste-enhanced foods KYOWA HAKKO FOOD SPECIALTIES CO., LTD. (JP) 2003-05-15 US disclosed
EP-1163853-A1 METHOD OF STRENGTHENIG THE TASTE OF SODIUM CHLORIDE, AGENT FOR STRENGTHENING THE TASTE OF SODIUM CHLORIDE, SODIUM CHLORIDE-TASTE SEASONING AND FOOD HAVING STRENGTHENED TASTE OF SODIUM CHLORIDE KYOWA HAKKO KOGYO CO., LTD. (JP) 2001-12-19 EP disclosed