Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.31 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495138 | 0.93 | KCNH2 (0.37) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5494489 | 0.86 | SLC6A2 (0.40) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5493839 | 0.83 | P2RX7 (0.39) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5499016 | 0.80 | KCNH2 (0.38) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5498352 | 0.79 | DRD2 (0.34) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5502511 | 0.79 | TAAR1 (0.45) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5495293 | 0.76 | P2RX7 (0.38) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5499300 | 0.76 | SLC6A2 (0.45) | KCNH2SLC6A2SLC6A4TACR1P2RX7 | |
| SCHEMBL5501439 | 0.74 | FFAR4 (0.40) | KCNH2SLC6A2SLC6A4SLC6A3TACR1 | |
| SCHEMBL5499318 | 0.72 | KCNH2 (0.33) | KCNH2SLC6A2SLC6A4SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765779-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005121092-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |