Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | PRKCG | P05129 | 2/20 | 0.37 |
| ▸ | PRKCB | P05771 | 2/20 | 0.37 |
| ▸ | PRKCA | P17252 | 2/20 | 0.37 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.37 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.37 |
| ▸ | STK16 | O75716 | 1/20 | 0.37 |
| ▸ | PAK3 | O75914 | 1/20 | 0.37 |
| ▸ | CDK14 | O94921 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5513194 | 0.87 | L3MBTL1 (0.46) | L3MBTL1HRH3KDM4ESMN1; SMN2TRPV6 | |
| SCHEMBL5503886 | 0.86 | CHRM1 (0.41) | L3MBTL1HRH3KDM4ESMN1; SMN2TRPV6 | |
| SCHEMBL5118837 | 0.85 | L3MBTL1 (0.43) | L3MBTL1HRH3KDM4ESMN1; SMN2TRPV6 | |
| SCHEMBL5507817 | 0.84 | L3MBTL1 (0.51) | L3MBTL1HRH3KDM4ESMN1; SMN2TRPV6 | |
| SCHEMBL5505801 | 0.82 | DRD4 (0.46) | HRH3KDM4ESMN1; SMN2DRD4PARP1 | |
| SCHEMBL5504518 | 0.80 | KDM1A (0.40) | KDM4ECYP2D6CYP1A2 | |
| SCHEMBL5504478 | 0.80 | CYP2D6 (0.41) | HRH3SMN1; SMN2PIM1CYP2D6CYP1A2 | |
| SCHEMBL5506174 | 0.76 | KDM1A (0.35) | SMN1; SMN2PIM1KMT2A | |
| SCHEMBL5112122 | 0.75 | CHRM1 (0.46) | L3MBTL1HRH3KDM4ESMN1; SMN2TRPV6 | |
| SCHEMBL5112936 | 0.73 | DRD2 (0.40) | L3MBTL1HRH3KDM4ESMN1; SMN2TRPV6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |