Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 8/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504478 | 0.85 | CYP2D6 (0.41) | KDM1ABCHESLC6A3PIM1HTR2C | |
| SCHEMBL5507708 | 0.84 | LMNA (0.40) | KDM1ABCHESLC6A3HTR2CHTR2A | |
| SCHEMBL3168391 | 0.81 | PIM1 (0.41) | KDM1ABCHESLC6A3PIM1HTR2C | |
| SCHEMBL38663158 | 0.79 | KDM1A (0.47) | KDM1ABCHESLC6A3HTR2CHTR2A | |
| SCHEMBL12537100 | 0.79 | KDM1A (0.47) | KDM1ABCHESLC6A3HTR2CHTR2A | |
| SCHEMBL5507974 | 0.79 | MKNK1 (0.36) | KDM1APIM1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5504518 | 0.79 | KDM1A (0.40) | KDM1AHTR2CHTR2A | |
| SCHEMBL5514484 | 0.78 | KDM1A (0.30) | KDM1A | |
| SCHEMBL5505801 | 0.77 | DRD4 (0.46) | KDM1ASMN1; SMN2 | |
| SCHEMBL5508467 | 0.70 | CHRM2 (0.43) | KDM1ABCHESLC6A3HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |