Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.46 |
| ▸ | DRD3 | P35462 | 6/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5111674 | 0.85 | DRD4 (0.43) | DRD4DRD3DRD2CHRM2CHRM3 | |
| SCHEMBL5502776 | 0.82 | L3MBTL1 (0.42) | DRD4PARP1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL5504518 | 0.80 | KDM1A (0.40) | KDM4EMAPTKDM1A | |
| SCHEMBL5504478 | 0.80 | CYP2D6 (0.41) | DRD3CHRM2CHRM3SMN1; SMN2HRH3 | |
| SCHEMBL5506174 | 0.77 | KDM1A (0.35) | SMN1; SMN2KDM1A | |
| Acetamide SCHEMBL27689339 | 0.72 | PARP1 (0.45) | DRD4DRD3DRD2CHRM2CHRM3 | |
| SCHEMBL5119371 | 0.72 | OPRM1 (0.47) | PARP1ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL8008100 | 0.71 | DRD4 (0.45) | DRD4DRD3DRD2CHRM2CHRM3 | |
| SCHEMBL5512320 | 0.70 | HRH3 (0.41) | DRD4DRD3DRD2CHRM2CHRM3 | |
| SCHEMBL5500227 | 0.70 | PARP1 (0.41) | DRD4DRD3DRD2CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |