Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 4/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | ACACA | Q13085 | 1/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502143 | 0.83 | NCF1 (0.50) | ALDH1A1HPGDHTR2AKDM4ETSHR | |
| SCHEMBL5502924 | 0.80 | KDM4E (0.52) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL6218194 | 0.73 | HTR4 (0.50) | ACACBACACA | |
| SCHEMBL9216241 | 0.73 | ALDH1A1 (0.62) | ALDH1A1HPGDHTR2AKDM4ETSHR | |
| SCHEMBL5637369 | 0.73 | KDM4E (0.47) | ALDH1A1KDM4EMEN1KMT2ANCF1 | |
| SCHEMBL27476078 | 0.72 | ALDH1A1 (0.51) | ALDH1A1HPGDHTR2AKDM4ETSHR | |
| SCHEMBL30777649 | 0.71 | ADRB1 (0.49) | HTR2AADRB1HTR6 | |
| SCHEMBL8219392 | 0.71 | ADRB1 (0.49) | HTR2AADRB1HTR6 | |
| Acetic Acid SCHEMBL27476079 | 0.71 | ALDH1A1 (0.53) | ALDH1A1HPGDHTR2AKDM4ETSHR | |
| SCHEMBL11574360 | 0.71 | ALDH1A1 (0.50) | ALDH1A1HPGDHTR2AKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218353-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2007-10-17 | — | — | EP | disclosed |
| EP-1272185-B1 | USE OF QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |