Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500736 | 0.75 | KMT2A (0.35) | KMT2AL3MBTL1HPGDSMN1; SMN2P2RX7 | |
| SCHEMBL5500067 | 0.72 | KMT2A (0.36) | KMT2AL3MBTL1SMN1; SMN2P2RX7RECQL | |
| SCHEMBL5499828 | 0.72 | DPP4 (0.38) | KMT2AHPGDSMN1; SMN2P2RX7RECQL | |
| SCHEMBL5505772 | 0.72 | KMT2A (0.35) | KMT2AL3MBTL1HPGDSMN1; SMN2P2RX7 | |
| SCHEMBL5500075 | 0.71 | PDCD1LG2 (0.35) | KMT2AL3MBTL1HPGDSMN1; SMN2P2RX7 | |
| SCHEMBL4130462 | 0.71 | DPP4 (0.38) | KMT2AL3MBTL1SMN1; SMN2P2RX7 | |
| SCHEMBL4747804 | 0.68 | KMT2A (0.50) | KMT2AL3MBTL1HPGDSMN1; SMN2P2RX7 | |
| SCHEMBL5506443 | 0.67 | DPP4 (0.35) | KMT2AL3MBTL1HPGDSMN1; SMN2P2RX7 | |
| SCHEMBL2989995 | 0.65 | P2RX7 (0.32) | L3MBTL1P2RX7 | |
| SCHEMBL2989997 | 0.65 | P2RX7 (0.32) | L3MBTL1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |