Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | USP5 | P45974 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506094 | 0.82 | LMNA (0.50) | MAPTPOLBACLYLMNATSHR | |
| SCHEMBL4955695 | 0.73 | USP5 (0.52) | MAPTPOLBUSP5ACLYALDH1A1 | |
| SCHEMBL4955014 | 0.72 | USP5 (0.48) | MAPTPOLBUSP5ACLYALDH1A1 | |
| SCHEMBL4955012 | 0.72 | DRD2 (0.50) | MAPTPOLBUSP5ACLYALDH1A1 | |
| SCHEMBL1103992 | 0.71 | HTT (0.57) | MAPTUSP5ACLYALDH1A1RAB9A | |
| SCHEMBL2155443 | 0.68 | DRD2 (0.49) | MAPTPOLBUSP5ACLYALDH1A1 | |
| SCHEMBL942429 | 0.67 | MMP13 (0.67) | KCNH2 | |
| SCHEMBL1983277 | 0.66 | HPGD (0.63) | MAPTPOLBALDH1A1HPGDNPSR1 | |
| SCHEMBL5510215 | 0.66 | DRD2 (0.52) | POLBUSP5ACLYLMNADRD2 | |
| SCHEMBL294302 | 0.65 | THRB (0.65) | MAPTUSP5ALDH1A1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828160-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | LABORATOIRES SERONO S.A. (CH) | 2007-09-05 | — | — | EP | claimed |
| WO-2006067114-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-06-29 | — | — | WO | claimed |