SCHEMBL5504024

SCHEMBL5504024

CC(C)(C)c1[c]c2[nH]c3cc(C(C)(C)C)ccc3c2cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 12/20 0.54
SCN10A Q9Y5Y9 2/20 0.39
KCNH2 Q12809 1/20 0.39
MAPT P10636 1/20 0.36
ALDH1A1 P00352 1/20 0.35
HPGD P15428 1/20 0.35
ALOX15 P16050 1/20 0.35
HSD17B10 Q99714 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
GHSR Q92847 1/20 0.33
PLK4 O00444 1/20 0.32
CHEK1 O14757 1/20 0.32
AURKA O14965 1/20 0.32
CHUK O15111 1/20 0.32
PDPK1 O15530 1/20 0.32
JAK2 O60674 1/20 0.32
ROCK2 O75116 1/20 0.32
MAP4K4 O95819 1/20 0.32
PAK4 O96013 1/20 0.32
CHEK2 O96017 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9010052 0.80 KIF11 (0.49) KIF11ALDH1A1HPGDHSD17B10
SCHEMBL29539315 0.78 KIF11 (0.81) KIF11SCN10AKCNH2MAPTALDH1A1
SCHEMBL2606005 0.78 KIF11 (0.81) KIF11SCN10AKCNH2MAPTALDH1A1
Bromide SCHEMBL30567841 0.77 KIF11 (0.78) KIF11SCN10AKCNH2MAPTALDH1A1
SCHEMBL15847628 0.75 CNR2 (0.40) KIF11
SCHEMBL23327761 0.72 KIF11 (0.76) KIF11GHSRCHUK
SCHEMBL31228901 0.72 KIF11 (0.76) KIF11GHSRCHUK
SCHEMBL30881120 0.72 KIF11 (0.76) KIF11GHSRCHUK
SCHEMBL29362207 0.70 KIF11 (1.00) KIF11ALDH1A1HSD17B10PLK4CHEK1
SCHEMBL24839388 0.70 KIF11 (0.68) KIF11MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240199777-A1 AMINO-BENZIMIDAZOLE CATALYSTS FOR THE PREPARATION OF POLYOLEFINS DOW GLOBAL TECHNOLOGIES LLC (US) 2024-06-20 US claimed
EP-4298136-A1 AMINO-BENZIMIDAZOLE CATALYSTS FOR THE PREPARATION OF POLYOLEFINS Dow Global Technologies LLC (US) 2024-01-03 EP claimed
CN-116964110-A Amino-benzimidazole catalysts for preparing polyolefins 陶氏环球技术有限责任公司 2023-10-27 CN claimed
WO-2022183008-A9 AMINO-BENZIMIDAZOLE CATALYSTS FOR THE PREPARATION OF POLYOLEFINS DOW GLOBAL TECHNOLOGIES LLC (US) 2023-10-12 WO claimed
EP-3356430-B1 A POLYMERIZATION PROCESS FOR PRODUCING ETHYLENE BASED POLYMERS DOW GLOBAL TECHNOLOGIES LLC (US) 2022-06-22 EP claimed
EP-3596138-B1 CATALYST SYSTEM FOR MULTI-BLOCK COPOLYMER FORMATION DOW GLOBAL TECHNOLOGIES LLC (US) 2024-04-03 EP disclosed
US-11459409-B2 Catalyst system for multi-block copolymer formation DOW GLOBAL TECHNOLOGIES LLC (US) 2022-10-04 US disclosed
EP-3356430-B1 A POLYMERIZATION PROCESS FOR PRODUCING ETHYLENE BASED POLYMERS DOW GLOBAL TECHNOLOGIES LLC (US) 2022-06-22 EP disclosed
EP-3436488-B1 AN OLEFIN POLYMERIZATION CATALYST DOW GLOBAL TECHNOLOGIES LLC (US) 2022-05-18 EP disclosed
US-11214632-B2 Bis-ligated phosphaguanidine group IV metal complexes and olefin polymerization catalysts produced therefrom DOW GLOBAL TECHNOLOGIES LLC (US) 2022-01-04 US disclosed
EP-3596141-B1 CATALYST SYSTEM FOR MULTI-BLOCK COPOLYMER FORMATION DOW GLOBAL TECHNOLOGIES LLC (US) 2021-07-28 EP disclosed
US-11066495-B2 Phosphaguanidine group IV metal olefin polymerization catalysts DOW GLOBAL TECHNOLOGY LLC (US) 2021-07-20 US disclosed
US-7241714-B2 Bridged bi-aromatic catalysts, complexes, and methods of using the same SYMYX TECHNOLOGIES, INC. (US) 2007-07-10 US disclosed
EP-1751169-A1 BRIDGED BI-AROMATIC CATALYSTS, COMPLEXES, AND METHOD OF USING THE SAME Symyx Technologies, Inc. (US) 2007-02-14 EP disclosed
US-20060205588-A1 Bridged bi-aromatic catalysts, complexes, and methods of using the same SYMYX TECHNOLOGIES, INC. (US) 2006-09-14 US disclosed
US-7091292-B2 Bridged bi-aromatic catalysts, complexes, and methods of using the same SYMYX TECHNOLOGIES, INC. (US) 2006-08-15 US disclosed
US-7060848-B2 Bridged bi-aromatic catalysts, complexes, and methods of using the same SYMYX TECHNOLOGIES, INC. (US) 2006-06-13 US disclosed
US-20060052554-A1 Bridged bi-aromatic catalysts, complexes, and methods of using the same SYMYX TECHNOLOGIES, INC. (US) 2006-03-09 US disclosed
US-20060025548-A1 BRIDGED BI-AROMATIC CATALYSTS, COMPLEXES, AND METHODS OF USING THE SAME SYMYX TECHNOLOGIES, INC. (US) 2006-02-02 US disclosed
WO-2005108406-A1 BRIDGED BI-AROMATIC CATALYSTS, COMPLEXES, AND METHOD OF USING THE SAME SYMYX TECNOLOGIES, INC (US) 2005-11-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11066495-B2 Phosphaguanidine group IV metal olefin polymerization catalysts POLG, ODC1, RNGTT KIF11 3630/4885SCN10A 1305/4885KCNH2 660/4885
US-20060052554-A1 Bridged bi-aromatic catalysts, complexes, and methods of using the same PCNA, BICRA, PCBP1 KIF11 3883/4885SCN10A 4681/4885KCNH2 4354/4885
US-11214632-B2 Bis-ligated phosphaguanidine group IV metal complexes and olefin polymerization catalysts produced therefrom BPGM, POLM, PARG KIF11 3385/4885SCN10A 4490/4885KCNH2 2952/4885
US-20240199777-A1 AMINO-BENZIMIDAZOLE CATALYSTS FOR THE PREPARATION OF POLYOLEFINS IL4I1, BCAT1, PARG KIF11 2799/4885SCN10A 4493/4885KCNH2 2644/4885
US-20060205588-A1 Bridged bi-aromatic catalysts, complexes, and methods of using the same PCNA, BICRA, PCBP1 KIF11 3883/4885SCN10A 4681/4885KCNH2 4354/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.